Počet záznamů: 1
Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL through Posttranslational Downregulation of c-FLIP
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SYSNO ASEP 0503586 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL through Posttranslational Downregulation of c-FLIP Tvůrce(i) Piggott, L. (GB)
Silva, A. (GB)
Robinson, T. (GB)
Santiago-Gomez, A. (GB)
Simoes, B. M. (GB)
Becker, M. (DE)
Fichtner, I. (DE)
Anděra, Ladislav (BTO-N)
Young, P. (GB)
Morris, Ch. (GB)
Barrett-Lee, P. (GB)
Alchami, F. (GB)
Piva, M. (ES)
Vivanco, M. D. (ES)
Clarke, R. B. (GB)
Gee, J. (GB)
Clarkson, R. (GB)Celkový počet autorů 17 Zdroj.dok. Clinical Cancer Research. - : American Association for Cancer Research - ISSN 1078-0432
Roč. 24, č. 10 (2018), s. 2452-2463Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova FLICE inhibitory protein recombinant tumor necrosis factor related apoptosis inducing ligand ; fulvestrant ; recombinant tumor necrosis factor related apoptosis inducing ligand Vědní obor RIV FD - Onkologie a hematologie Obor OECD Oncology Institucionální podpora BTO-N - RVO:86652036 UT WOS 000432329600024 EID SCOPUS 85046169877 DOI 10.1158/1078-0432.CCR-17-1381 Anotace Purpose: One third of ER-positive breast cancer patients who initially respond to endocrine therapy become resistant to treatment. Such treatment failure is associated with poor prognosis and remains an area of unmet clinical need. Here, we identify a specific posttranslational modification that occurs during endocrine resistance and which results in tumor susceptibility to the apoptosis-inducer TRAIL. This potentially offers a novel stratified approach to targeting endocrine-resistant breast cancer. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2019
Počet záznamů: 1