Počet záznamů: 1  

Remodeling of tick cytoskeleton in response to infection with Anaplasma phagocytophilum

  1. 1.
    SYSNO ASEP0478939
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevRemodeling of tick cytoskeleton in response to infection with Anaplasma phagocytophilum
    Tvůrce(i) Cabezas Cruz, Alejandro (BC-A)
    Alberdi, P. (ES)
    Valdés, James J. (BC-A) RID, ORCID
    Villar, M. (ES)
    de la Fuente, J. (ES)
    Celkový počet autorů5
    Zdroj.dok.Frontiers in Bioscience-Landmark - ISSN 1093-4715
    Roč. 22, Jun 1 (2017), s. 1830-1844
    Poč.str.15 s.
    Forma vydáníTištěná - P
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovacytoskeleton ; proteomics ; transcriptomics ; Ixodes scapularis ; Anaplasma phagocytophilum
    Vědní obor RIVEB - Genetika a molekulární biologie
    Obor OECDBiochemistry and molecular biology
    Způsob publikováníOmezený přístup
    Institucionální podporaBC-A - RVO:60077344
    UT WOS000439039200001
    EID SCOPUS85027704584
    DOI10.2741/4574
    AnotaceThe obligate intracellular pathogen Anaplasma phagocytophilum infects vertebrate and tick hosts. In this study, a genome-wide search for cytoskeleton components was performed in the tick vector, Ixodes scapularis. The available transcriptomics and proteomics data was then used to characterize the mRNA and protein levels of I. scapularis cytoskeleton components in response to A. phagocytophilum infection. The results showed that cytoskeleton components described in other model organisms were present in the I. scapularis genome. One type of intermediate filaments (lamin), a family of septins that was recently implicated in the cellular response to intracellular pathogens, and several members of motor proteins (kinesins and dyneins) that could be implicated in the cytoplasmic movements of A. phagocytophilum were found. The results showed that levels of tubulin, actin, septin, actin-related proteins and motor proteins were affected by A. phagocytophilum, probably to facilitate infection in I. scapularis. Functional studies demonstrated a role for selected cytoskeleton components in pathogen infection. These results provided a more comprehensive view of the cytoskeletal components involved in the response to A. phagocytophilum infection in ticks.
    PracovištěBiologické centrum (od r. 2006)
    KontaktDana Hypšová, eje@eje.cz, Tel.: 387 775 214
    Rok sběru2018
    Elektronická adresahttps://www.bioscience.org/2017/v22/af/4574/list.htm
Počet záznamů: 1  

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