Počet záznamů: 1
Remodeling of tick cytoskeleton in response to infection with Anaplasma phagocytophilum
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SYSNO ASEP 0478939 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Remodeling of tick cytoskeleton in response to infection with Anaplasma phagocytophilum Tvůrce(i) Cabezas Cruz, Alejandro (BC-A)
Alberdi, P. (ES)
Valdés, James J. (BC-A) RID, ORCID
Villar, M. (ES)
de la Fuente, J. (ES)Celkový počet autorů 5 Zdroj.dok. Frontiers in Bioscience-Landmark - ISSN 1093-4715
Roč. 22, Jun 1 (2017), s. 1830-1844Poč.str. 15 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova cytoskeleton ; proteomics ; transcriptomics ; Ixodes scapularis ; Anaplasma phagocytophilum Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Biochemistry and molecular biology Způsob publikování Omezený přístup Institucionální podpora BC-A - RVO:60077344 UT WOS 000439039200001 EID SCOPUS 85027704584 DOI 10.2741/4574 Anotace The obligate intracellular pathogen Anaplasma phagocytophilum infects vertebrate and tick hosts. In this study, a genome-wide search for cytoskeleton components was performed in the tick vector, Ixodes scapularis. The available transcriptomics and proteomics data was then used to characterize the mRNA and protein levels of I. scapularis cytoskeleton components in response to A. phagocytophilum infection. The results showed that cytoskeleton components described in other model organisms were present in the I. scapularis genome. One type of intermediate filaments (lamin), a family of septins that was recently implicated in the cellular response to intracellular pathogens, and several members of motor proteins (kinesins and dyneins) that could be implicated in the cytoplasmic movements of A. phagocytophilum were found. The results showed that levels of tubulin, actin, septin, actin-related proteins and motor proteins were affected by A. phagocytophilum, probably to facilitate infection in I. scapularis. Functional studies demonstrated a role for selected cytoskeleton components in pathogen infection. These results provided a more comprehensive view of the cytoskeletal components involved in the response to A. phagocytophilum infection in ticks. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2018 Elektronická adresa https://www.bioscience.org/2017/v22/af/4574/list.htm
Počet záznamů: 1