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Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation
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SYSNO ASEP 0475702 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation Tvůrce(i) Petrovič, Miloš (FGU-C)
da Silva, S. V. (FR)
Clement, J. P. (IN)
Vyklický ml., Ladislav (FGU-C) RID, ORCID, SAI
Mulle, C. (FR)
González-González, I. M. (GB)
Henley, J. M. (GB)Zdroj.dok. Nature Neuroscience. - : Nature Publishing Group - ISSN 1097-6256
Roč. 20, č. 4 (2017), s. 529-539Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova hippocampus ; long-term potentiation ; membrane proteins Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Obor OECD Neurosciences (including psychophysiology CEP GA17-02300S GA ČR - Grantová agentura ČR Institucionální podpora FGU-C - RVO:67985823 UT WOS 000397558800008 EID SCOPUS 85012279012 DOI 10.1038/nn.4505 Anotace Long-term potentiation (LTP) in the rat hippocampus is the most extensively studied cellular model for learning and memory. Induction of classical LTP involves an NMDA-receptor-and calcium-dependent increase in functional synaptic AMPA receptors, mediated by enhanced recycling of internalized AMPA receptors back to the postsynaptic membrane. Here we report a physiologically relevant NMDA-receptor-independent mechanism that drives increased AMPA receptor recycling and LTP. This pathway requires the metabotropic action of kainate receptors and activation of G protein, protein kinase C and phospholipase C. Like classical LTP, kainate-receptor-dependent LTP recruits recycling endosomes to spines, enhances synaptic recycling of AMPA receptors to increase their surface expression and elicits structural changes in spines, including increased growth and maturation. These data reveal a new and, to our knowledge, previously unsuspected role for postsynaptic kainate receptors in the induction of functional and structural plasticity in the hippocampus. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2018
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