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Natural compound Ganoderma lucidum influences survival and migration of colorectal and pancreatic cell lines
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SYSNO ASEP 0475625 Druh ASEP C - Konferenční příspěvek (mezinárodní konf.) Zařazení RIV O - Ostatní Název Natural compound Ganoderma lucidum influences survival and migration of colorectal and pancreatic cell lines Tvůrce(i) Macinga, P. (CZ)
Opattová, Alena (UEM-P)
Čumová, Andrea (UEM-P)
Horák, Josef (UEM-P) ORCID
Slíva, D. (CZ)
Hucl, T. (CZ)
Vodička, Pavel (UEM-P) RIDZdroj.dok. Cellular signalling and cancer therapy. - Cavtat : EMBO Conference, 2016 Rozsah stran s. 153-153 Poč.str. 1 s. Akce Cellular signalling and cancer therapy Datum konání 27.05.2016 - 31.05.2016 Místo konání Cavtat Země HR - Chorvatsko Jazyk dok. eng - angličtina Země vyd. HR - Chorvatsko Klíč. slova metastatic cancers ; natural compound ; colorectal cell lines ; pancreatic cell lines ; survival ; migration Vědní obor RIV EB - Genetika a molekulární biologie CEP LH13061 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA15-14789S GA ČR - Grantová agentura ČR GAP301/12/1734 GA ČR - Grantová agentura ČR Institucionální podpora UEM-P - RVO:68378041 Anotace Metastases are considered to be a major complication in patients with many types of cancers. Metastatic, or stage IV colon cancer patients, have a 5-year relative survival rate around 11% and pancreatic cancer patients less than 5%. The most common sites of metastases of colorectal and pancreatic cancer are liver, lungs and peritoneum. Identification of compounds with anti-metastatic effect may affect the disease progression, delay the spread of the disease and in addition elongate the relative survival of cancer patients. Ganoderma lucidum (GLC) is a medical mushroom, used in traditional Chinese medicine with declared anticancer effect in vitro. Our study was aimed to investigate anti-proliferative and anti-migration effects of natural compound Ganoderma lucidum on colorectal and pancreatic cancer cell lines.
We have studied survival and migration of colorectal cancer (HCT116, HT29) and pancreatic cell lines (MiaPaca2, Panc1) after GLC treatment. Our results showed that 0.5µg/µl GLC decreased the survival of HCT116 by 25% (p<0.05). Moreover we observed this effect also in HT29 cell line (15%; p<0.05). In case of pancreatic cancer cells, GLC treatment decreased survival of Miapaca2 cells by about 36,5% (p<0.01) and Panc1 cells by around 48% (p<0.05). Finally, GLC extract decreased migration of CRC and pancreatic cell lines (HCT116, 64.32%, p<0.05 and HT29 52%, p<0.05).
Our results suggest that GLC extract significantly decreases cell survival and migration. This finding may lead to delay of the disease progression and natural compounds seem to be a potential supplement to classical cancer therapy.
Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2017
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