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Optical imaging of localized chemical events using programmable diamond quantum nanosensors
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SYSNO ASEP 0475005 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Optical imaging of localized chemical events using programmable diamond quantum nanosensors Tvůrce(i) Rendler, T. (DE)
Neburková, Jitka (UOCHB-X) RID, ORCID
Zemek, O. (CZ)
Kotek, J. (CZ)
Zappe, A. (DE)
Chu, Z. (DE)
Cígler, Petr (UOCHB-X) RID, ORCID
Wrachtrup, J. (DE)Číslo článku 14701 Zdroj.dok. Nature Communications. - : Nature Publishing Group
Roč. 8, Mar 20 (2017)Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova fluorescent nanodiamonds ; lanthanide(III) complexes ; ambient conditions Vědní obor RIV BO - Biofyzika Obor OECD Biophysics CEP GA16-16336S GA ČR - Grantová agentura ČR Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000396666300001 EID SCOPUS 85015807223 DOI 10.1038/ncomms14701 Anotace Development of multifunctional nanoscale sensors working under physiological conditions enables monitoring of intracellular processes that are important for various biological and medical applications. By attaching paramagnetic gadolinium complexes to nanodiamonds (NDs) with nitrogen-vacancy (NV) centres through surface engineering, we developed a hybrid nanoscale sensor that can be adjusted to directly monitor physiological species through a proposed sensing scheme based on NV spin relaxometry. We adopt a single-step method to measure spin relaxation rates enabling time-dependent measurements on changes in pH or redox potential at a submicrometre-length scale in a microfluidic channel that mimics cellular environments. Our experimental data are reproduced by numerical simulations of the NV spin interaction with gadolinium complexes covering the NDs. Considering the versatile engineering options provided by polymer chemistry, the underlying mechanism can be expanded to detect a variety of physiologically relevant species and variables. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Rok sběru 2018 Elektronická adresa https://www.nature.com/articles/ncomms14701
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