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Genetic variation in the major mitotic checkpoint genes associated with chromosomal aberrations in healthy humans
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SYSNO ASEP 0469310 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Genetic variation in the major mitotic checkpoint genes associated with chromosomal aberrations in healthy humans Tvůrce(i) Försti, A. (DE)
Frank, Ch. (DE)
Smolková, B. (SK)
Kazimírová, A. (SK)
Barančoková, M. (SK)
Vymetálková, Veronika (UEM-P) RID
Kroupa, M. (CZ)
Naccarati, Alessio (UEM-P)
Vodičková, Ludmila (UEM-P) RID
Buchancová, J. (SK)
Dusinská, M. (SK)
Musak, L. (SK)
Vodička, Pavel (UEM-P) RID
Hemminki, K. (DE)Zdroj.dok. Cancer letters. - : Elsevier - ISSN 0304-3835
Roč. 380, č. 2 (2016), s. 442-446Poč.str. 5 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova chromosomal integrity ; cytogenetics ; spindle checkpoint Vědní obor RIV EB - Genetika a molekulární biologie CEP GA15-14789S GA ČR - Grantová agentura ČR Institucionální podpora UEM-P - RVO:68378041 UT WOS 000383300300009 EID SCOPUS 84978639705 DOI 10.1016/j.canlet.2016.07.011 Anotace Non-specific chromosomal aberrations (CAs) are microscopically detected in about 1% of lymphocytes drawn from healthy persons. Causes of CAs in general population are not known but they may be related to risk of cancer. In view of the importance of the mitotic checkpoint machinery on maintaining chromosomal integrity we selected 9 variants in main checkpoint related genes (BUB1B, BUB3, MAD2L1, CENPF, ESPLI/separase, NEC, PTTGlisecurin, ZWILCH and ZWINT) for a genotyping study on samples from healthy individuals (N = 330 to 729) whose lymphocytes had an increased number of CAs compared to persons with a low number of CAs. Genetic variation in individual genes played a minor importance, consistent with the high conservation and selection pressure of the checkpoint system. However, gene pairs were significantly associated with CAs: PTTG1-ZWILCH and PTTG1-ZWINT. MAD2L1 and PTTG1 were the most common partners in any of the two-way interactions. The results suggest that interactions at the level of cohesin (PITG1) and kinetochore function (ZWINT, ZWILCH and MAD2L1) contribute to the frequency of CAs, suggesting that gene variants at different checkpoint functions appeared to be required for the formation of CAs. (C) 2016 Elsevier Ireland Ltd. All rights reserved. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2017
Počet záznamů: 1