Počet záznamů: 1
New cell motility model observed in parasitic cnidarian Sphaerospora molnari (Myxozoa: Myxosporea) blood stages in fish
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SYSNO ASEP 0468738 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název New cell motility model observed in parasitic cnidarian Sphaerospora molnari (Myxozoa: Myxosporea) blood stages in fish Tvůrce(i) Hartigan, Ashlie (BC-A) RID, ORCID
Estensoro, Itziar (BC-A)
Vancová, Marie (BC-A) RID, ORCID
Bílý, Tomáš (BC-A) ORCID
Patra, Sneha (BC-A) SAI
Eszterbauer, E. (HU)
Holzer, Astrid S. (BC-A) RID, ORCIDCelkový počet autorů 7 Číslo článku 39093 Zdroj.dok. Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 6, DEC 16 (2016)Poč.str. 12 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Enteromyxum leei ; Sparus aurata ; Myxobolus cerebralis ; immune response ; actin cytoskeleton ; Trypanosoma brucei ; gilthead seabream ; evolution ; host Vědní obor RIV EG - Zoologie CEP GBP505/12/G112 GA ČR - Grantová agentura ČR Institucionální podpora BC-A - RVO:60077344 UT WOS 000389887800001 EID SCOPUS 85022094008 DOI 10.1038/srep39093 Anotace Cellular motility is essential for microscopic parasites, it is used to reach the host, migrate through tissues, or evade host immune reactions. Many cells employ an evolutionary conserved motor protein-actin, to crawl or glide along a substrate. We describe the peculiar movement of Sphaerospora molnari, a myxozoan parasite with proliferating blood stages in its host, common carp. Myxozoa are highly adapted parasitic cnidarians alternately infecting vertebrates and invertebrates. S. molnari blood stages (SMBS) have developed a unique "dancing" behaviour, using the external membrane as a motility effector to rotate and move the cell. SMBS movement is exceptionally fast compared to other myxozoans, non-directional and constant. The movement is based on two cytoplasmic actins that are highly divergent from those of other metazoans. We produced a specific polyclonal actin antibody for the staining and immunolabelling of S. molnari's microfilaments since we found that neither commercial antibodies nor phalloidin recognised the protein or microfilaments. We show the in situ localization of this actin in the parasite and discuss the importance of this motility for evasion from the cellular host immune response in vitro. This new type of motility holds key insights into the evolution of cellular motility and associated proteins. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2017
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