Počet záznamů: 1
Structural chromosomal aberrations as potential risk markers in incident cancer patients
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SYSNO ASEP 0451439 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Structural chromosomal aberrations as potential risk markers in incident cancer patients Tvůrce(i) Vodenková, Soňa (UEM-P) ORCID, RID
Polívková, Z. (CZ)
Musak, L. (SK)
Smerhovský, Z. (CZ)
Zoubková, H. (CZ)
Sytarová, S. (CZ)
Kavcová, E. (CZ)
Halasová, E. (SK)
Vodičková, Ludmila (UEM-P) RID
Jirásková, Kateřina (UEM-P)
Svoboda, Miroslav (UEM-P)
Ambruš, M. (CZ)
Hemminki, K. (DE)
Vodička, Pavel (UEM-P) RIDCelkový počet autorů 14 Zdroj.dok. Mutagenesis. - : Oxford University Press - ISSN 0267-8357
Roč. 30, č. 4 (2015), s. 557-563Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova peripheral-blood lymphocytes ; dna-repair genes ; healthy humans ; polymorphisms ; frequency ; damage ; biomarkers ; association ; carcinogens ; instability Vědní obor RIV EB - Genetika a molekulární biologie CEP LD14050 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UEM-P - RVO:68378041 UT WOS 000357885900011 EID SCOPUS 84936748157 DOI 10.1093/mutage/gev018 Anotace Epidemiological prospective studies have shown that increased chromosomal aberrations (CAs) in peripheral blood lymphocytes may predict cancer risk. Here, we report CAs in newly diagnosed 101 colorectal, 87 lung and 158 breast cancer patients and corresponding healthy controls. Strong differences in distributions of aberrant cells (ACs), CAs, chromatid-type aberrations (CTAs) and chromosome-type aberrations (CSAs) were observed in lung and breast cancer patients as compared to healthy controls. In colorectal cancer (CRC) patients, only CTAs were significantly elevated. Binary logistic regression, adjusted for main confounders, indicates that all the analysed cytogenetic parameters along with smoking were significantly associated with breast and lung cancer risks. Significant differences in terminal deletions between breast cancer patients and corresponding female controls were recorded (0.39 vs. 0.18; P <= 0.05). We did not find any association of CAs with TNM (tumor nodus metastasis) stages or histopathological grade in either cancer type. CAs were neither associated with additional tumor characteristics-invasivity, ductal and lobular character, estrogene/progesterone receptors in breast tumors nor with non-small/small cell and bronchogenic/pulmonary types of lung tumors. Our study demonstrates that CAs serve as a predictive marker for breast and lung cancer, whereas only CTAs were elevated in incident CRC patients. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2016
Počet záznamů: 1