Evaluation of a Novel Maghemite Hybrid Nanocarrier for MR Imaging (Pilot Study)

0446113 - ÚPT 2016 RIV SK eng C - Konferenční příspěvek (zahraniční konf.)
Malá, Aneta - Bakandritsos, A. - Macíček, Ondřej - Rousalis, E. - Dražanová, Eva - Jiřík, Radovan - Dvořáková, Lenka - Krátká, Lucie - Starčuk jr., Zenon
Evaluation of a Novel Maghemite Hybrid Nanocarrier for MR Imaging (Pilot Study).
Measurement 2015. Proceedings of the 10th International Conference on Measurement. Bratislava: Institute of Measurement Science, SAS, 2015, s. 121-124. ISBN 978-80-969672-9-2.
[International Conference on Measurement /10./. Smolenice (SK), 25.05.2015-28.05.2015]
Grant CEP: GA MŠMT(CZ) LO1212
Institucionální podpora: RVO:68081731
Klíčová slova: nanocarrier * maghemite * contrast agent * MRI
Kód oboru RIV: BH - Optika, masery a lasery

The aim of this study was to investigate Mag 102-6, a maghemite hybrid drug nanocarrier, as a potential T2 contrast agent (CA) for magnetic resonance imaging (MRI). Samples of agar gel mixed with different Fe concentrations of Mag 102-6 were measured at laboratory temperature for relaxivity r2 determination in 9.4 T. The results were compared with commercial CA FeraSpin XXL measured in the same arrangement. In addition, the r2 of Mag 102-6 in saline solution at physiological temperature 37.7 degree Celsius was measured. MRI was performed with four mice using a 9.4T NMR scanner before, and up to 24 h post-injection (p.i.) of Mag 102-6 (dose 5 mg Fe kg-1). Images of abdomen were continuously acquired by segmented Multi Gradient Echo (MGE) pulse sequence from 1 minute before the CA application to 20 minutes p.i. The T1-weighted (T1-w) and T2-weighted (T2-w) images were captured before the application and 25 minutes, 3.5, 7 and 24 hours after CA application. R2 changes in time were estimated from MGE images for various anatomical regions (kidney, muscles, liver) by fitting of signal intensities. Mag 102-6 and FeraSpin XXL had comparable r2 values. Mag 102-6 showed the potential to be monitored by MRI as a T2 CA.
Trvalý link: http://hdl.handle.net/11104/0248091