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Cationization of heparin for film applications
- 1.
SYSNO ASEP 0439595 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Cationization of heparin for film applications Tvůrce(i) Šimkovic, I. (SK)
Mendichi, R. (IT)
Kelnar, Ivan (UMCH-V) RID, ORCID
Filip, J. (SK)
Hricovíni, M. (SK)Zdroj.dok. Carbohydrate Polymers. - : Elsevier - ISSN 0144-8617
Roč. 115, 22 January (2015), s. 551-558Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova heparin ; cationization ; NMR Vědní obor RIV CD - Makromolekulární chemie Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000344869800072 EID SCOPUS 84907546152 DOI 10.1016/j.carbpol.2014.09.021 Anotace Trimethylammonium-2-hydroxypropyl-(TMAHP) spacer was introduced into heparin (H) and the prepared films were characterized by elemental analysis, NMR, SEC-MALS, TG/DTG/DTA, AFM and mechanical tester. When quaternized at the ratio of H/NaOH/alkylating agent/H2O = 0.1-1/0-2/0.1-1/50-500 mmol, H was substituted at A6 and A3 positions. The formation of double-substituted structures by substitution of free hydroxyl group of the previously introduced TMAHP substituent is evident. In the absence of NaOH (H/GTMAC/H2O = 1:1:500) the most drastic decrease of Mn to 8.639 kg/mol and Mw/Mn at 1.48 was observed in comparison to H (Mn = 9532 g/mol with Mw/Mn = 1.38). The film mechanical properties were better on H (E = 4030 MPa; σb = 65 MPa; ɛb = 4.6%) than on quaternized specimens (E = 2500–3340 MPa; σb = 25–40 MPa; ɛb = 1.7–1.8%). The AFM images did not prove relation between mechanical properties and surface shape. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2016
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