Počet záznamů: 1
2'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein
- 1.0580601 - ÚOCHB 2024 RIV eng P - Patentový dokument
Birkuš, Gabriel - Páv, Ondřej - Jandušík, Tomáš - Rosenberg, Ivan - Nencka, Radim
2'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein.
2023. Vlastník: Ústav organické chemie a biochemie AV ČR, v. v. i. Datum udělení patentu: 22.11.2023. Číslo patentu: EP3728282. Teritoriální ochrana: evropský patent podle Evropské patentové úmluvy ,mezinárodní patentová ochrana dle Smlouvy o patentové spolupráci.
Grant CEP: GA MŠMT(CZ) EF16_019/0000729
Institucionální podpora: RVO:61388963
Klíčová slova: STING * cyclic dinucleotide * agonist
Obor OECD: Organic chemistry
https://worldwide.espacenet.com/patent/search/family/065244413/publication/EP3728282B1?q=EP3728282B1
The present disclosure relates to 2′3′ cyclic phosphonate dinucleotides of general formula (J), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.
Trvalý link: https://hdl.handle.net/11104/0349363
Počet záznamů: 1