Počet záznamů: 1  

G-quadruplexes in the evolution of hepatitis B virus

  1. 1.
    SYSNO ASEP0574515
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevG-quadruplexes in the evolution of hepatitis B virus
    Tvůrce(i) Brázda, Václav (BFU-R) RID, ORCID
    Dobrovolná, Michaela (BFU-R)
    Bohalova, Natalia (BFU-R) ORCID
    Mergny, Jean-Louis (BFU-R) ORCID, RID
    Celkový počet autorů4
    Zdroj.dok.Nucleic Acids Research. - : Oxford University Press - ISSN 0305-1048
    Roč. 51, č. 14 (2023), s. 7198-7204
    Poč.str.7 s.
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovaFORMING SEQUENCES ; GENOME ; TRANSCRIPTION
    Vědní obor RIVCE - Biochemie
    Obor OECDBiochemistry and molecular biology
    CEPEF15_003/0000477 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
    GA22-21903S GA ČR - Grantová agentura ČR
    Způsob publikováníOpen access
    Institucionální podporaBFU-R - RVO:68081707
    UT WOS001018208100001
    EID SCOPUS85168061458
    DOI10.1093/nar/gkad556
    AnotaceHepatitis B virus (HBV) is one of the most dangerous human pathogenic viruses found in all corners of the world. Recent sequencing of ancient HBV viruses revealed that these viruses have accompanied humanity for several millenia. As G-quadruplexes are considered to be potential therapeutic targets in virology, we examined G-quadruplex-forming sequences (PQS) in modern and ancient HBV genomes. Our analyses showed the presence of PQS in all 232 tested HBV genomes, with a total number of 1258 motifs and an average frequency of 1.69 PQS per kbp. Notably, the PQS with the highest G4Hunter score in the reference genome is the most highly conserved. Interestingly, the density of PQS motifs is lower in ancient HBV genomes than in their modern counterparts (1.5 and 1.9/kb, respectively). This modern frequency of 1.90 is very close to the PQS frequency of the human genome (1.93) using identical parameters. This indicates that the PQS content in HBV increased over time to become closer to the PQS frequency in the human genome. No statistically significant differences were found between PQS densities in HBV lineages found in different continents. These results, which constitute the first paleogenomics analysis of G4 propensity, are in agreement with our hypothesis that, for viruses causing chronic infections, their PQS frequencies tend to converge evolutionarily with those of their hosts, as a kind of 'genetic camouflage' to both hijack host cell transcriptional regulatory systems and to avoid recognition as foreign material.
    PracovištěBiofyzikální ústav
    KontaktJana Poláková, polakova@ibp.cz, Tel.: 541 517 244
    Rok sběru2024
    Elektronická adresahttps://academic.oup.com/nar/article/51/14/7198/7217046?login=true
Počet záznamů: 1  

  Tyto stránky využívají soubory cookies, které usnadňují jejich prohlížení. Další informace o tom jak používáme cookies.