Počet záznamů: 1
Voltammetric studies of selected porphyrin G-quadruplex ligands and their interaction with DNA in solution and at the mercury electrode surface
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SYSNO ASEP 0546616 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Voltammetric studies of selected porphyrin G-quadruplex ligands and their interaction with DNA in solution and at the mercury electrode surface Tvůrce(i) Dobrovodský, Daniel (BFU-R) ORCID
Daňhel, Aleš (BFU-R) RID, ORCID
Mothes-Martin, E. (FR)
Pratviel, G. (FR)
Mergny, Jean-Louis (BFU-R) ORCID, RID
Fojta, Miroslav (BFU-R) RID, ORCIDCelkový počet autorů 6 Číslo článku 139151 Zdroj.dok. Electrochimica acta. - : Elsevier - ISSN 0013-4686
Roč. 394, OCT 20 2021 (2021)Poč.str. 11 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova cationic porphyrins ; metal-complexes ; binding ; metalloporphyrins ; selectivity Vědní obor RIV CG - Elektrochemie Obor OECD Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis) CEP EF15_003/0000477 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora BFU-R - RVO:68081707 UT WOS 000703171900001 EID SCOPUS 85114124634 DOI 10.1016/j.electacta.2021.139151 Anotace With the increasing interest in DNA G-quadruplexes (G4) as important regulatory elements and prospective therapeutical targets, DNA structure-sensitive electrochemical methods can be advantageously used for studying of their structure or screening for interactions with G4 ligands developed as candidate drugs. Porphyrin derivatives are among the most prominent classes of G4 ligands. Interactions of porphyrins H 2TMPy2PP and Cu-TMPy2PP with oligodeoxynucleotides (ODNs) either forming or not forming G4 were investigated in this work. For this purpose, cyclic voltammetry at hanging mercury drop electrode (HMDE) complemented by UV-vis and CD spectroscopy was applied. Both porphyrins were found to interact strongly with G4 in solution by UV-vis titrations. However, Cu-TMPy2PP appears to interact also with double-stranded and single-stranded ODNs. Accordingly, cyclic voltammetry was able to distinguish between free and ODN-bound forms of Cu-TMPy2PP, but not between binding of the ligand to ODNs with or without G4 propensity. (C) 2021 Elsevier Ltd. All rights reserved. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2022 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0013468621014419?via%3Dihub
Počet záznamů: 1