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Trigeminal neuropathic pain is alleviated by inhibition of Cav3.3 T-type calcium channels in mice
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SYSNO ASEP 0539125 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Trigeminal neuropathic pain is alleviated by inhibition of Cav3.3 T-type calcium channels in mice Tvůrce(i) Montera, M. (US)
Goins, A. (US)
Cmarko, Leoš (UOCHB-X) ORCID
Weiss, Norbert (UOCHB-X) ORCID, RID
Westlund, K. N. (US)
Alles, S. R. A. (US)Zdroj.dok. Channels . - : Taylor & Francis - ISSN 1933-6950
Roč. 15, č. 1 (2021), s. 31-37Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova neuropathic pain ; calcium channels ; Cav3.3 ; trigeminal nerve injury ; therapeutics Vědní obor RIV CE - Biochemie Obor OECD Biochemistry and molecular biology Způsob publikování Open access Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000601365100001 EID SCOPUS 85097974403 DOI 10.1080/19336950.2020.1859248 Anotace In this brief report, we demonstrate that the Cav3.3 T-type voltage-gated calcium channel subtype is involved in our FRICT-ION model of chronic trigeminal neuropathic pain. We first showed that the Cacna1i gene encoding Cav3.3 is significantly upregulated in whole trigeminal ganglia of FRICT-ION mice compared to controls at week 10 post-injury. We confirmed protein upregulation of Cav3.3 compared to controls using Western blot analysis of whole trigeminal ganglia tissues. Finally, we demonstrated that intraperitoneal injection of a selective TAT-based Cav3.3 blocking peptide in FRICT-ION mice significantly reduces Cav3.3 protein expression at the peak anti-allodynic effect (4 hrs post-injection) of the attenuated neuropathic pain behavior. We also suggest that blockade of Cav3.3 may be more effective in attenuating trigeminal neuropathic pain in female than male FRICT-ION mice. Therefore, blocking or attenuating Cav3.3 function may be an effective strategy for the treatment of trigeminal neuropathic pain. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Rok sběru 2022 Elektronická adresa https://doi.org/10.1080/19336950.2020.1859248
Počet záznamů: 1