Počet záznamů: 1
Arbitrarily-shaped microgels composed of chemically unmodified biopolymers
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SYSNO ASEP 0531596 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Arbitrarily-shaped microgels composed of chemically unmodified biopolymers Tvůrce(i) Vakkipurath Kodakkadan, Y. N. (CZ)
Idzakovicova, K. (CZ)
Šepitka, J. (CZ)
ten Napel, D. (NL)
Safai, E. (NL)
Cígler, Petr (UOCHB-X) RID, ORCID
Štěpánek, F. (CZ)
Řehoř, Ivan (UOCHB-X) RID, ORCIDZdroj.dok. Biomaterials Science . - : Royal Society of Chemistry - ISSN 2047-4830
Roč. 8, č. 11 (2020), s. 3044-3051Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova stop-flow lithography ; biomedical applications ; cross-linking Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP EF16_019/0000729 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000539368700021 EID SCOPUS 85085904242 DOI 10.1039/c9bm02056j Anotace Biohydrogels, composed of naturally occurring biopolymers are typically preferred over their synthetic analogues in bioapplications thanks to their biocompatibility, bioactivity, mechanical or degradation properties. Shaping biohydrogels on the single-cell length scales (micrometers) is a key ability needed to create bioequivalent artificial cell/tissue constructs and cannot be achieved with current methods. This work introduces a method for photolithographic synthesis of arbitrarily shaped microgels composed purely of a biopolymer of choice. The biopolymer is mixed with a sacrificial photocrosslinkable polymer, and the mixture is photocrosslinked in a lithographic process, yielding anisotropic microgels with the biopolymer entrapped in the network. Subsequent ionic or covalent biopolymer crosslinking followed by template cleavage yields a microgel composed purely of a biopolymer with the 3D shape dictated by the photocrosslinking process. Method feasibility is demonstrated with two model polysaccharide biopolymers (alginate, chitosan) using suitable crosslinking methods. Next, alginate microgels were used as microtaggants on a pharmaceutical oral solid dose formulation to prevent its counterfeiting. Since the alginate is approved as an additive in the food and pharmaceutical industries, the presented tagging system can be implemented in practical use much easier than systems comprising synthetic polymers. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Rok sběru 2021 Elektronická adresa https://doi.org/10.1039/C9BM02056J
Počet záznamů: 1