Počet záznamů: 1
Capillary isotachophoresis with electrospray-ionization mass-spectrometric detection: Cationic electrolyte systems in the medium- alkaline range for selective analysis of medium strong bases
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SYSNO ASEP 0524028 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Capillary isotachophoresis with electrospray-ionization mass-spectrometric detection: Cationic electrolyte systems in the medium- alkaline range for selective analysis of medium strong bases Tvůrce(i) Malá, Zdeňka (UIACH-O) RID
Gebauer, Petr (UIACH-O) RID, ORCIDCelkový počet autorů 2 Číslo článku 460907 Zdroj.dok. Journal of Chromatography A. - : Elsevier - ISSN 0021-9673
Roč. 1618, May (2020)Poč.str. 8 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova capillary isotachophoresis ; dried blood spots ; ESI–MS detection ; medium-alkaline pH Vědní obor RIV CB - Analytická chemie, separace Obor OECD Analytical chemistry CEP GA18-13135S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora UIACH-O - RVO:68081715 UT WOS 000528932300016 EID SCOPUS 85079051884 DOI 10.1016/j.chroma.2020.460907 Anotace This work extends the present working range of isotachophoresis (ITP) with electrospray-ionization mass-spectrometric (ESI–MS) detection and describes for the first time a functional cationic electrolyte system for analyses at medium-alkaline pH. So far no ITP–MS application was published on the analysis of medium strong bases although there is a broad spectrum of potential analytes like biogenic amines, alkaloids or drugs, where this technique promises interesting gains in both sensitivity and specificity. The presented results include a selection of suitable sufficiently volatile ESI-compatible system components, discussion of factors affecting system properties, and recommendations for functional ITP electrolyte systems. Theoretical conclusions based on calculations and computer simulations are confirmed by experiments with a model mixture of beta-blockers. Practical applicability of the method is demonstrated on the example of analysis of sotalol in dried blood spots where direct injection of aqueous extract, ITP stacking and MS detection provide a fast, simple and sensitive technique with limits of quantitation on the sub-nM level. Pracoviště Ústav analytické chemie Kontakt Iveta Drobníková, drobnikova@iach.cz, Tel.: 532 290 234 Rok sběru 2021 Elektronická adresa http://hdl.handle.net/11104/0308342
Počet záznamů: 1