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The comprehensive in vitro evaluation of eight different calcium phosphates: Significant parameters for cell behavior
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SYSNO ASEP 0506357 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The comprehensive in vitro evaluation of eight different calcium phosphates: Significant parameters for cell behavior Tvůrce(i) Šupová, Monika (USMH-B) RID, ORCID, SAI
Suchý, Tomáš (USMH-B) RID, ORCID, SAI
Sucharda, Zbyněk (USMH-B)
Filová, Elena (FGU-C) RID, ORCID
der Kinderen, J.N.L.M. (NL)
Steinerová, Marie (FGU-C) ORCID
Bačáková, Lucie (FGU-C) RID, ORCID
Martynková, G.S. (CZ)Zdroj.dok. Journal of the American Ceramic Society. - : Wiley - ISSN 0002-7820
Roč. 102, č. 5 (2019), s. 2882-2904Poč.str. 23 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Calcium phosphate ; Nanoparticles ; Osteoblasts ; In vitro tests Vědní obor RIV FI - Traumatologie, ortopedie Obor OECD Medical engineering Vědní obor RIV – spolupráce Fyziologický ústav - Biotechnologie a bionika CEP NV15-25813A GA MZd - Ministerstvo zdravotnictví NV15-32497A GA MZd - Ministerstvo zdravotnictví GA15-01558S GA ČR - Grantová agentura ČR ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora USMH-B - RVO:67985891 ; FGU-C - RVO:67985823 UT WOS 000460080000065 EID SCOPUS 85054560045 DOI 10.1111/jace.16110 Anotace Eight different calcium phosphate nanoparticles, namely bovine bone bioapatite calcined at 500, 600, and 700 degrees C, Mg-doped brushite, fluorinated calcium phosphate, Ca-deficient hydroxyapatite, hydroxyapatite, and tricalcium phosphate, were characterized employing physico-chemical methods. Their cytocompatibility was evaluated under human osteoblast-like cell line MG-63 culture conditions in elution media and via the direct interaction of cells with calcium phosphate nanoparticles. The main objective was to determine the correlation of the cell indices with the differently determined physical and chemical parameters of the calcium phosphates. Chemical composition, which contributes toward pH changes, and the calcium ion concentration in the medium appear to make up particularly significant factors, moreover, it was proved that the number of material types represents a further important aspect. In the case of a large number of material types, almost no correlation was determined between the analyzed parameters, however, in the case of a small number of apatite types, several positive correlations were found. It can be concluded that it is not possible to identify any monitored parameters that had a major impact on cell behavior or, at least, such an effect which can be generalized. It appears more likely that cell behavior is affected by the interplay of various parameters. Pracoviště Ústav struktury a mechaniky hornin Kontakt Iva Švihálková, svihalkova@irsm.cas.cz, Tel.: 266 009 216 Rok sběru 2020 Elektronická adresa https://ceramics.onlinelibrary.wiley.com/doi/abs/10.1111/jace.16110
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