Počet záznamů: 1
A detailed study of the ion chemistry of alkenes focusing on heptenes aimed at their SIFT-MS quantification
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SYSNO ASEP 0497667 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název A detailed study of the ion chemistry of alkenes focusing on heptenes aimed at their SIFT-MS quantification Tvůrce(i) Michalčíková, R. (CZ)
Dryahina, Kseniya (UFCH-W) RID, ORCID
Španěl, Patrik (UFCH-W) RID, ORCIDZdroj.dok. International Journal of Mass Spectrometry. - : Elsevier - ISSN 1387-3806
Roč. 425, FEB 2018 (2018), s. 16-21Poč.str. 6 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova tube mass-spectrometry ; inflammatory-bowel-disease ; volatile organic-compounds ; trace gas-analysis ; flow tube Vědní obor RIV CF - Fyzikální chemie a teoretická chemie Obor OECD Physical chemistry CEP GA13-28882S GA ČR - Grantová agentura ČR Institucionální podpora UFCH-W - RVO:61388955 UT WOS 000425743600003 EID SCOPUS 85039774288 DOI 10.1016/j.ijms.2017.12.004 Anotace Analyses of trace amounts of alkene vapours present in exhaled breath are becoming important in clinical research related to inflammatory bowel disease, IBD, currently affecting over 1 million patients in the USA and 2.5 million in Europe. Concentrations of alkenes have been previously found to be different in the breath of IBD patients in comparison with healthy controls and are suggested as potential biomarkers of IBD activity. Thus, a detailed selected ion flow tube, SIFT, study of the reactions of H3O+, NO+ and O-2(+center dot) with a homologous series of alkenes (from 1-hexene to 1-decene) and with additional isomers of heptene (trans-2-heptene and a mixture of cis- and trans-3-heptene) has been carried out. The rate coefficients of all primary reactions and product ion branching ratios of the reactions of H3O+ and NO+ ions were obtained, which are necessary for accurate quantification of alkenes by selected ion flow tube mass spectrometry, SIFT-MS. The results of the present study facilitate analyses of these compounds in real breath samples with the ultimate aim of establishing their clinical use. (C) 2017 Elsevier B.V. All rights reserved. Pracoviště Ústav fyzikální chemie J.Heyrovského Kontakt Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Rok sběru 2019
Počet záznamů: 1