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The role of the hippocampus in object discrimination based on visual features
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SYSNO ASEP 0496243 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The role of the hippocampus in object discrimination based on visual features Tvůrce(i) Levčík, David (FGU-C) RID, ORCID
Nekovářová, Tereza (FGU-C) RID, ORCID
Antošová, Eliška (FGU-C)
Stuchlík, Aleš (FGU-C) RID, ORCID
Klement, Daniel (FGU-C) RIDZdroj.dok. Neurobiology of Learning and Memory. - : Elsevier - ISSN 1074-7427
Roč. 155, Nov (2018), s. 127-135Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova hippocampus ; object discrimination ; visual discrimination ; operant conditioning ; muscimol Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Obor OECD Neurosciences (including psychophysiology CEP GA17-04047S GA ČR - Grantová agentura ČR LM2015062 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora FGU-C - RVO:67985823 UT WOS 000449310000014 EID SCOPUS 85050125438 DOI 10.1016/j.nlm.2018.06.003 Anotace The role of rodent hippocampus has been intensively studied in different cognitive tasks. However, its role in discrimination of objects remains controversial due to conflicting findings. We tested whether the number and type of features available for the identification of objects might affect the strategy (hippocampal-independent vs. hippocampal-dependent) that rats adopt to solve object discrimination tasks. We trained rats to discriminate 2D visual objects presented on a computer screen. The objects were defined either by their shape only or by multiple-features (a combination of filling pattern and brightness in addition to the shape). Our data showed that objects displayed as simple geometric shapes are not discriminated by trained rats after their hippocampi had been bilaterally inactivated by the GABAA-agonist muscimol. On the other hand, objects containing a specific combination of non-geometric features in addition to the shape are discriminated even without the hippocampus. Our results suggest that the involvement of the hippocampus in visual object discrimination depends on the abundance of object’s features. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2019
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