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Anchored but not internalized: shape dependent endocytosis of nanodiamond
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SYSNO ASEP 0483228 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Anchored but not internalized: shape dependent endocytosis of nanodiamond Tvůrce(i) Zhang, B. (CN)
Feng, X. (CN)
Yin, H. (CN)
Ge, Z. (CN)
Wang, Y. H. (CN)
Chu, Z. (CN)
Raabová, Helena (UOCHB-X)
Vávra, Jan (UOCHB-X)
Cígler, Petr (UOCHB-X) RID, ORCID
Liu, R. (CN)
Wang, Y. (CN)
Li, Q. (CN)Číslo článku 46462 Zdroj.dok. Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 7, Apr 13 (2017)Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova fluorescent nanodiamonds ; surface chemistry ; vesicle membranes Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Cell biology CEP NV15-33094A GA MZd - Ministerstvo zdravotnictví 7AMB16FR029 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000399030800001 EID SCOPUS 85017420978 DOI 10.1038/srep46462 Anotace Nanoparticle-cell interactions begin with the cellular uptake of the nanoparticles, a process that eventually determines their cellular fate. In the present work, we show that the morphological features of nanodiamonds (NDs) affect both the anchoring and internalization stages of their endocytosis. While a prickly ND (with sharp edges/corners) has no trouble of anchoring onto the plasma membrane, it suffers from difficult internalization afterwards. In comparison, the internalization of a round ND (obtained by selective etching of the prickly ND) is not limited by its lower anchoring amount and presents a much higher endocytosis amount. Molecular dynamics simulation and continuum modelling results suggest that the observed difference in the anchoring of round and prickly NDs likely results from the reduced contact surface area with the cell membrane of the former, while the energy penalty associated with membrane curvature generation, which is lower for a round ND, may explain its higher probability of the subsequent internalization. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Rok sběru 2018 Elektronická adresa https://www.nature.com/articles/srep46462
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