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The transcriptional repressor HIC1 regulates intestinal immune homeostasis
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SYSNO ASEP 0481982 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The transcriptional repressor HIC1 regulates intestinal immune homeostasis Tvůrce(i) Burrows, K. (CA)
Antignano, F. (CA)
Bramhall, M. (AU)
Chenery, A. (CA)
Scheer, S. (AU)
Kořínek, Vladimír (UMG-J) RID
Underhill, T. M. (CA)
Zaph, C. (CA)Celkový počet autorů 8 Zdroj.dok. Mucosal Immunology. - : Springer - ISSN 1933-0219
Roč. 10, č. 6 (2017), s. 1518-1528Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova cd4(+) t-cells ; anti-interleukin-17 monoclonal-antibody ; cd103(+) dendritic cells ; acid receptor-alpha ; retinoic acid ; t(h)17 cells ; target genes ; double-blind ; tgf-beta ; differentiation Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Biochemistry and molecular biology Institucionální podpora UMG-J - RVO:68378050 UT WOS 000413119700013 DOI 10.1038/mi.2017.17 Anotace The intestine is a unique immune environment that must respond to infectious organisms but remain tolerant to commensal microbes and food antigens. However, the molecular mechanisms that regulate immune cell function in the intestine remain unclear. Here we identify the POK/ZBTB family transcription factor hypermethylated in cancer 1 (HIC1, ZBTB29) as a central component of immunity and inflammation in the intestine. HIC1 is specifically expressed in immune cells in the intestinal lamina propria (LP) in the steady state and mice with a T-cell-specific deletion of HIC1 have reduced numbers of T cells in the LP. HIC1 expression is regulated by the Vitamin A metabolite retinoic acid, as mice raised on a Vitamin A-deficient diet lack HIC1-positive cells in the intestine. HIC1-deficient T cells overproduce IL-17A in vitro and in vivo, and fail to induce intestinal inflammation, identifying a critical role for HIC1 in the regulation of T-cell function in the intestinal microenvironment under both homeostatic and inflammatory conditions. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2018
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