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The chemical profile and pharmacodynamic properties of extracellular Wollea saccata biopolymer
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SYSNO ASEP 0478834 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The chemical profile and pharmacodynamic properties of extracellular Wollea saccata biopolymer Tvůrce(i) Šutovská, M. (SK)
Kočmálová, M. (SK)
Pappová, L. (SK)
Fraňová, S. (SK)
Chyba, A. (SK)
Kopecký, Jiří (MBU-M) ORCID
Lukavský, Jaromír (BU-J) RID, ORCID
Cepák, Vladislav (BU-J) RID
Capek, P. (SK)Zdroj.dok. International Journal of Biological Macromolecules. - : Elsevier - ISSN 0141-8130
Roč. 103, OCT 2017 (2017), s. 863-869Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Wollea saccata ; Extracellular proteoglycan ; Pharmacodynamic properties Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology Vědní obor RIV – spolupráce Botanický ústav - Biotechnologie a bionika CEP TE01020080 GA TA ČR - Technologická agentura ČR Institucionální podpora MBU-M - RVO:61388971 ; BU-J - RVO:67985939 UT WOS 000408286400099 EID SCOPUS 85019673689 DOI 10.1016/j.ijbiomac.2017.05.014 Anotace Microalgae organisms are of interest for many biotechnology applications due to the production of a wide range of biologically active compounds. Incubation of Wollea saccata in a large scale afforded a mucilaginous, high molecular weight biopolymer composed of carbohydrate, protein and phenolic compounds. Sugar moiety was rich in hexoses (60%) and 6-deoxyhexoses (31%), while only 9% of pentoses was identified. Methylation analysis revealed about 40 types of methylated sugar derivatives, suggesting a very complex structure of Wollea biopolymer. Pharmacological studies revealed new pharmacodynamic properties of cyanobacteria biopolymer, i.e. antitussive and bronchodilatory. Biopolymer was able to suppress the cough reflex induced by chemical tussigen, but its effect was lower than that of codeine, the strongest antitussive agent. The bronchodilatory effect was similar or higher than the effect of salbutamol, a bronchodilatory drug used in a clinical practice. In pharmacological studies, there were no signs of toxicity or side effects in the animals following administration of Wollea biopolymer. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2018
Počet záznamů: 1