Počet záznamů: 1
Effect of Colloidal Silica on Rheological Properties of Common Pharmaceutical Excipients.
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SYSNO ASEP 0468966 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Effect of Colloidal Silica on Rheological Properties of Common Pharmaceutical Excipients. Tvůrce(i) Majerová, D. (CZ)
Kulaviak, Lukáš (UCHP-M) RID, ORCID, SAI
Růžička, Marek (UCHP-M) RID, ORCID, SAI
Štěpánek, F. (CZ)
Zámostný, P. (CZ)Zdroj.dok. European Journal of Pharmaceutics and Biopharmaceutics. - : Elsevier - ISSN 0939-6411
Roč. 106, SI (2016), s. 2-8Poč.str. 7 s. Akce International Granulation Workshop /7./ Datum konání 29.06.2015 - 03.07.2015 Místo konání Sheffield Země GB - Velká Británie Typ akce EUR Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova powder flow ; cohesion ; glidants Vědní obor RIV CI - Průmyslová chemie a chemické inženýrství CEP GA15-05534S GA ČR - Grantová agentura ČR Institucionální podpora UCHP-M - RVO:67985858 UT WOS 000382338100002 EID SCOPUS 84969506987 DOI 10.1016/j.ejpb.2016.04.025 Anotace In this work, rheological properties of four common excipients were studied by the FT4 Powder Rheometer, which was used for measuring the compressibility index by a piston and flow properties of the powders by a rotational shear cell. After an initial set of measurements, two excipients were chosen and mixed, in varying amounts, with anhydrous colloidal silicon dioxide (Aerosil 200) used as a glidant. The bulk (conditioned and compressed densities, dynamic (basic flow energy) and shear (friction coefficient, flow factor) properties were determined to find an optimum ratio of the glidant. Simultaneously, the particle size data were obtained using a low-angle laser light scattering (LALLS) system and scanning electron microscopy was performed in order to examine the relationship between the rheological properties and the inner structure of the materials. The optimum of flowability for the mixture composition was found, to correspond to empirical findings known from general literature. In addition the mechanism of colloidal silicone dioxide action to improve flowabitlity was suggested and the hypothesis was confirmed by independent test. New findings represent a progress towards future application of determining the optimum concentration of glidant from the basic characteristics of the powder in the pharmaceutical research and development. Pracoviště Ústav chemických procesů Kontakt Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Rok sběru 2017
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