Počet záznamů: 1  

Double-strand break repair and colorectal cancer: gene variants within 3' UTRs and microRNAs binding as modulators of cancer risk and clinical outcome.

  1. 1.
    SYSNO ASEP0459496
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevDouble-strand break repair and colorectal cancer: gene variants within 3' UTRs and microRNAs binding as modulators of cancer risk and clinical outcome.
    Tvůrce(i) Naccarati, Alessio (UEM-P)
    Rosa, F. (IT)
    Vymetálková, Veronika (UEM-P) RID
    Barone, E. (IT)
    Jirásková, Kateřina (UEM-P)
    Gaetano, C. (IT)
    Novotný, J. (CZ)
    Levý, M. (CZ)
    Vodičková, Ludmila (UEM-P) RID
    Gemignani, F. (IT)
    Buchler, T. (CZ)
    Landi, S. (IT)
    Vodička, Pavel (UEM-P) RID
    Pardini, B. (IT)
    Zdroj.dok.OncoTarget. - : Impact Journals LLC - ISSN 1949-2553
    Roč. 7, č. 17 (2016), s. 23156-23169
    Poč.str.14 s.
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slova3'UTR polymorphisms ; colorectal cancer risk and clinical outcomes ; double-strand break repair (DSBR) genes
    Vědní obor RIVEB - Genetika a molekulární biologie
    CEPNV15-26535A GA MZd - Ministerstvo zdravotnictví
    GAP304/12/1585 GA ČR - Grantová agentura ČR
    GA15-14789S GA ČR - Grantová agentura ČR
    Institucionální podporaUEM-P - RVO:68378041
    UT WOS000377706200015
    EID SCOPUS84966549132
    DOI10.18632/oncotarget.6804
    AnotaceGenetic variations in 3' untranslated regions of target genes may affect microRNA binding, resulting in differential protein expression. microRNAs regulate DNA repair, and single-nucleotide polymorphisms in miRNA binding sites (miRSNPs) may account for interindividual differences in the DNA repair capacity. Our hypothesis is that miRSNPs in relevant DNA repair genes may ultimately affect cancer susceptibility and impact prognosis. In the present study, we analysed the association of polymorphisms in predicted microRNA target sites of double-strand breaks (DSBs) repair genes with colorectal cancer (CRC) risk and clinical outcome. Twenty-one miRSNPs in non-homologous end-joining and homologous recombination pathways were assessed in 1111 cases and 1469 controls. The variant CC genotype of rs2155209 in MRE11A was strongly associated with decreased cancer risk when compared with the other genotypes (OR 0.54, 95% CI 0.38-0.76, p = 0.0004). A reduced expression of the reporter gene was observed for the C allele of this polymorphism by in vitro assay, suggesting a more efficient interaction with potentially binding miRNAs. In colon cancer patients, the rs2155209 CC genotype was associated with shorter survival while the TT genotype of RAD52 rs11226 with longer survival when both compared with their respective more frequent genotypes (HR 1.63, 95% CI 1.06-2.51, p = 0.03 HR 0.60, 95% CI 0.41-0.89, p = 0.01, respectively). miRSNPs in DSB repair genes involved in the maintenance of genomic stability may have a role on CRC susceptibility and clinical outcome.
    PracovištěÚstav experimentální medicíny
    KontaktLenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
    Rok sběru2017
Počet záznamů: 1  

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