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Constitutive Negative Regulation of R Proteins in Arabidopsis also via Autophagy Related Pathway?
- 1.0459222 - ÚEB 2017 RIV CH eng J - Článek v odborném periodiku
Pečenková, Tamara - Sabol, P. - Kulich, I. - Ortmannová, Jitka - Žárský, Viktor
Constitutive Negative Regulation of R Proteins in Arabidopsis also via Autophagy Related Pathway?
Frontiers in Plant Science. Roč. 7, MAR 4 (2016), s. 260. ISSN 1664-462X. E-ISSN 1664-462X
Grant CEP: GA ČR(CZ) GA15-14886S
Institucionální podpora: RVO:61389030
Klíčová slova: resistance * autophagy * R
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 4.291, rok: 2016
Even though resistance (R) genes are among the most studied components of the plant immunity, there remain still a lot of aspects to be explained about the regulation of their function. Many gain-of-function mutants of R genes and loss-of-function of their regulators often demonstrate up-regulated defense responses in combination with dwarf stature and/or spontaneous leaf lesions formation. For most of these mutants, phenotypes are a consequence of an ectopic activation of R genes. Based on the compilation and comparison of published results in this field, we have concluded that the constitutively activated defense phenotypes recurrently arise by disruption of tight, constitutive and multilevel negative control of some of R proteins that might involve also their targeting to the autophagy pathway. This mode of R protein regulation is supported also by protein-protein interactions listed in available databases, as well as in silico search for autophagy machinery interacting motifs. The suggested model could resolve some explanatory discrepancies found in the studies of the immunity responses of autophagy mutants.
Trvalý link: http://hdl.handle.net/11104/0259454
Název souboru Staženo Velikost Komentář Verze Přístup 2016_Pecenkova_FRONTIERS IN PLANT SCIENCE_260.pdf 4 549.6 KB Jiná povolen
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