Suppression of alkali-induced oxidative injury in the cornea by mesenchymal stem cells growing on nanofiber scaffolds and transferred onto the damaged corneal surface

Čejková, Jitka; Trošan, Peter; Čejka, Čestmír; Lencová, A.; Zajícová, Alena; Javorková, Eliška; Kubinová, Šárka; Syková, Eva; Holáň, Vladimír

doi:https://dx.doi.org/10.1016/j.exer.2013.10.002

Počet záznamů: 1

Suppression of alkali-induced oxidative injury in the cornea by mesenchymal stem cells growing on nanofiber scaffolds and transferred onto the damaged corneal surface

1.

SYSNO ASEP	0398145
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Suppression of alkali-induced oxidative injury in the cornea by mesenchymal stem cells growing on nanofiber scaffolds and transferred onto the damaged corneal surface
Tvůrce(i)	Čejková, Jitka (UEM-P)_RID Trošan, Peter (UEM-P) Čejka, Čestmír (UEM-P)_RID Lencová, A. (CZ) Zajícová, Alena (UEM-P)_RID Javorková, Eliška (UEM-P)_RID Kubinová, Šárka (UEM-P)_{RID, ORCID} Syková, Eva (UEM-P)_RID Holáň, Vladimír (UEM-P)_RID
Celkový počet autorů	9
Zdroj.dok.	Experimental Eye Research. - : Elsevier - ISSN 0014-4835 Roč. 116, Nov. (2013), s. 312-323
Poč.str.	12 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	corneal oxidative injury ; mesenchymal stem cells ; nanofiber scaffolds
Vědní obor RIV	FF - ORL, oftalmologie, stomatologie
CEP	GAP304/11/0653 GA ČR - Grantová agentura ČR
	GAP301/11/1568 GA ČR - Grantová agentura ČR
Institucionální podpora	UEM-P - RVO:68378041
CEZ	AV0Z50390512 - UEM-P (2005-2011)
UT WOS	000327562500036
EID SCOPUS	84886857482
DOI	10.1016/j.exer.2013.10.002
Anotace	Nanofiber scaffolds seeded with rabbit bone marrow-derived mesenchymal stem cells (MSCs) were transferred onto the rabbit cornea, damaged with sodium hydroxide, causing oxidative injury in the cornea. MSCs protected the formation of toxic peroxynitrite in the cornea, lowered apoptotic cell death and decreased matrix metalloproteinase and proinflammatory cytokine production. This resulted in reduced corneal inflammation, neovascularization and significantly accelerated corneal healing. key words (3): corneal oxidative injury, mesenchymal stem cells, nanofiber scaffolds.
Pracoviště	Ústav experimentální medicíny
Kontakt	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Rok sběru	2014

Počet záznamů: 1