Počet záznamů: 1
Genetic variants in C-type lectin genes are associated with colorectal cancer susceptibility and clinical outcome
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SYSNO ASEP 0396305 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Genetic variants in C-type lectin genes are associated with colorectal cancer susceptibility and clinical outcome Tvůrce(i) Lu, S. (DE)
Bevier, M. (DE)
Huhn, S. (DE)
Sainz, J. (DE)
Lascorz, J. (DE)
Pardini, Barbara (UEM-P)
Naccarati, Alessio (UEM-P)
Vodičková, Ludmila (UEM-P) RID
Novotný, J. (CZ)
Hemminki, K. (DE)
Vodička, Pavel (UEM-P) RID
Försti, A. (DE)Celkový počet autorů 12 Zdroj.dok. International Journal of Cancer. - : Wiley - ISSN 0020-7136
Roč. 133, č. 10 (2013), s. 2325-2333Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova CD209 ; colorectal cancer ; polymorphism Vědní obor RIV EB - Genetika a molekulární biologie CEP GAP304/10/1286 GA ČR - Grantová agentura ČR GAP304/12/1585 GA ČR - Grantová agentura ČR Institucionální podpora UEM-P - RVO:68378041 UT WOS 000324072300007 EID SCOPUS 84883769767 DOI 10.1002/ijc.28251 Anotace Inflammatory responses play a vital role at different stages of colorectal carcinogenesis. C-type lectins mediate inflammatory/immune responses and participate in immune escape of pathogens and tumors. Our study aimed to evaluate the correlation between polymorphisms in three C-type lectin genes, CD209, MBL2 and REG4, and colorectal cancer (CRC) risk and clinical outcome. We genotyped 15 potentially functional single nucleotide polymorphisms (SNPs) and assessed their associations with CRC risk in a case-control study of 1353 CRC cases and 767 healthy controls from the Czech Republic. We also analyzed these SNPs in relation to overall and event-free survival in 414 patients. Minor allele carriers of the promoter SNP rs2287886 had an increased risk of CRC (OR 1.30, 95% CI 1.08-1.56), while minor allele carriers of the 3'UTR SNP, rs7248637, had a decreased risk (OR 0.74, 95% CI 0.60-0.91). Multivariate survival analyses, including age, gender, TNM stage and grade, showed that patients without distant metastasis at the time of diagnosis and carrying the rs2994809 T allele had a decreased overall and event-free survival (HR 2.11, 95% CI 1.20-3.72 and HR 2.00, 95% CI 1.18-3.39, respectively). We show that SNPs in CD209 may affect CRC risk, while a SNP in REG4 may be a useful marker for CRC progression. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2014
Počet záznamů: 1