Počet záznamů: 1
Implications of Altered Gene Expression in Embryo and Placenta during Diabetic Pregnancy
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SYSNO ASEP 0351895 Druh ASEP A - Abstrakt Zařazení RIV Záznam nebyl označen do RIV Zařazení RIV Není vybrán druh dokumentu Název Implications of Altered Gene Expression in Embryo and Placenta during Diabetic Pregnancy Tvůrce(i) Kappen, C. (US)
Pavlínková, Gabriela (BTO-N) RID, ORCID
Kruger, C. (US)
Salbaum, M. (US)Zdroj.dok. Birth Defects Research Part A-Clinical and Molecular Teratology - ISSN 1542-0752
Roč. 85, č. 5 (2009), s. 410-410Poč.str. 1 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Embryopathy ; microarrays ; placenta Vědní obor RIV EB - Genetika a molekulární biologie CEZ AV0Z50520701 - BTO-N (2007-2013) Anotace Diabetes during pregnancy is a known risk factor for congenital malformations of the cardiovascular system and for neural tube defects. Using genome-wide expression prolifing, we have shown that the exposure is associated with deregulated gene expression in the developing embryo. Altered gene expression was also evident in the diabetic placenta, where a different repertoire of genes is misexpressed. This indicates that responses to metabolic imbalance employ specific pathways in tissue- and cell-type-specific manner, thus implicating multiple and distinct gene-environment interactions in birth defects risk under conditions of diabetic pregnancy. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2011
Počet záznamů: 1