Počet záznamů: 1
Higher antibody titres against Pseudogymnoascus destructans are associated with less white-nose syndrome skin lesions in Palearctic bats
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SYSNO ASEP 0580381 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Higher antibody titres against Pseudogymnoascus destructans are associated with less white-nose syndrome skin lesions in Palearctic bats Tvůrce(i) Pikula, J. (CZ)
Brichta, J. (CZ)
Seidlová, V. (CZ)
Piaček, V. (CZ)
Zukal, Jan (UBO-W) RID, ORCID, SAICelkový počet autorů 5 Číslo článku 1269526 Zdroj.dok. Frontiers in Immunology. - : Frontiers Media - ISSN 1664-3224
Roč. 14, DEC (2023)Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova emerging wildlife infection ; adaptive antifungal immunity ; disease severity ; indirect ELISA ; antibody prevalence ; Myotis bat species Vědní obor RIV GJ - Choroby a škůdci zvířat, veterinární medicína Obor OECD Veterinary science Způsob publikování Open access Institucionální podpora UBO-W - RVO:68081766 UT WOS 001128768400001 EID SCOPUS 85180522891 DOI 10.3389/fimmu.2023.1269526 Anotace Introduction: Serological tests can be used to test whether an animal has been exposed to an infectious agent, and whether its immune system has recognized and produced antibodies against it. Paired samples taken several weeks apart then document an ongoing infection and/or seroconversion.
Methods: In the absence of a commercial kit, we developed an indirect enzyme-linked immunosorbent assay (ELISA) to detect the fungus-specific antibodies for Pseudogymnoascus destructans, the agent of white-nose syndrome in bats.
Results and Discussion: Samples collected from European Myotis myotis (n=35) and Asian Myotis dasycneme (n=11) in their hibernacula at the end of the hibernation period displayed 100% seroprevalence of antibodies against P. destructans, demonstrating a high rate of exposure. Our results showed that the higher the titre of antibodies against P. destructans, the lower the infection intensity, suggesting that a degree of protection is provided by this arm of adaptive immunity in Palearctic bats. Moreover, P. destructans infection appears to be a seasonally self-limiting disease of Palearctic bats showing seroconversion as the WNS skin lesions heal in the early post-hibernation period.Pracoviště Ústav biologie obratlovců Kontakt Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Rok sběru 2024 Elektronická adresa https://www.frontiersin.org/articles/10.3389/fimmu.2023.1269526/full
Počet záznamů: 1