Počet záznamů: 1
The extracellular matrix and perineuronal nets in memory
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SYSNO ASEP 0566580 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The extracellular matrix and perineuronal nets in memory Tvůrce(i) Fawcett, James (UEM-P) ORCID
Fyhn, M. (NO)
Jendelová, Pavla (UEM-P) RID, ORCID
Kwok, Jessica (UEM-P) ORCID, RID
Růžička, Jiří (UEM-P)
Sorg, B.A. (US)Zdroj.dok. Molecular Psychiatry. - : Springer - ISSN 1359-4184
Roč. 27, č. 8 (2022), s. 3192-3203Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova medial prefrontal cortex ; chondroitin sulfate proteoglycans ; hippocampal synaptic plasticity ; conditioned place preference ; long-term potentiation Obor OECD Neurosciences (including psychophysiology CEP EF15_003/0000419 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA19-10365S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UEM-P - RVO:68378041 UT WOS 000816996400001 DOI 10.1038/s41380-022-01634-3 Anotace All components of the CNS are surrounded by a diffuse extracellular matrix (ECM) containing chondroitin sulphate proteoglycans (CSPGs), heparan sulphate proteoglycans (HSPGs), hyaluronan, various glycoproteins including tenascins and thrombospondin, and many other molecules that are secreted into the ECM and bind to ECM components. In addition, some neurons, particularly inhibitory GABAergic parvalbumin-positive (PV) interneurons, are surrounded by a more condensed cartilage-like ECM called perineuronal nets (PNNs). PNNs surround the soma and proximal dendrites as net-like structures that surround the synapses. Attention has focused on the role of PNNs in the control of plasticity, but it is now clear that PNNs also play an important part in the modulation of memory. In this review we summarize the role of the ECM, particularly the PNNs, in the control of various types of memory and their participation in memory pathology. PNNs are now being considered as a target for the treatment of impaired memory. There are many potential treatment targets in PNNs, mainly through modulation of the sulphation, binding, and production of the various CSPGs that they contain or through digestion of their sulphated glycosaminoglycans. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2023 Elektronická adresa https://www.nature.com/articles/s41380-022-01634-3
Počet záznamů: 1