Počet záznamů: 1
Polyenic antibiotics and other antifungal compounds produced by hemolytic Streptomyces species
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SYSNO ASEP 0565131 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Polyenic antibiotics and other antifungal compounds produced by hemolytic Streptomyces species Tvůrce(i) Bobek, J. (CZ)
Filipová, E. (CZ)
Bergman, N. (CZ)
Čihák, M. (CZ)
Petříček, M. (CZ)
Lara, Ana Catalina (BC-A) RID, ORCID
Krištůfek, Václav (BC-A) RID
Megyes, M. (HU)
Wurzer, T. (AT)
Chroňáková, Alica (BC-A) RID, ORCID
Petříčková, K. (CZ)Číslo článku 15045 Zdroj.dok. International Journal of Molecular Sciences. - : MDPI
Roč. 23, č. 23 (2022)Poč.str. 22 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova Actinomycetales ; secondary metabolites ; polyene antibiotics ; Streptomyces ; hemolysis ; symbiosis ; soil ecosystem Vědní obor RIV CE - Biochemie Obor OECD Biochemistry and molecular biology CEP NV17-30091A GA MZd - Ministerstvo zdravotnictví GA17-22572S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora BC-A - RVO:60077344 UT WOS 000939115000001 EID SCOPUS 85143702895 DOI 10.3390/ijms232315045 Anotace Streptomyces are of great interest in the pharmaceutical industry as they produce a plethora of secondary metabolites that act as antibacterial and antifungal agents. They may thrive on their own in the soil, or associate with other organisms, such as plants or invertebrates. Some soil-derived strains exhibit hemolytic properties when cultivated on blood agar, raising the question of whether hemolysis could be a virulence factor of the bacteria. In this work we examined hemolytic compound production in 23 β-hemolytic Streptomyces isolates, of these 12 were soil-derived, 10 were arthropodassociated, and 1 was plant-associated. An additional human-associated S. sp. TR1341 served as a control. Mass spectrometry analysis suggested synthesis of polyene molecules responsible for the hemolysis: candicidins, filipins, strevertene A, tetrafungin, and tetrin A, as well as four novel polyene compounds (denoted here as polyene A, B, C, and D) in individual liquid cultures or paired cocultures. The non-polyene antifungal compounds actiphenol and surugamide A were also identified. The findings indicate that the ability of Streptomyces to produce cytolytic compounds (here manifested by hemolysis on blood agar) is an intrinsic feature of the bacteria in the soil environment and could even serve as a virulence factor when colonizing available host organisms. Additionally, a literature review of polyenes and non-polyene hemolytic metabolites produced by Streptomyces is presented. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2023 Elektronická adresa https://www.mdpi.com/1422-0067/23/23/15045
Počet záznamů: 1