Počet záznamů: 1
Effects of aqueous systems and stabilization membranes on the separation of an antibiotic precursor in a microextractor
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SYSNO ASEP 0561869 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Effects of aqueous systems and stabilization membranes on the separation of an antibiotic precursor in a microextractor Tvůrce(i) Sauer, L. (CZ)
Kralik, D. (CZ)
Izák, Pavel (UCHP-M) RID, ORCID, SAI
Slouka, Z. (CZ)
Přibyl, M. (CZ)Číslo článku 121050 Zdroj.dok. Separation and Purification Technology. - : Elsevier - ISSN 1383-5866
Roč. 292, JUL 1 (2022)Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova microextractor ; membrane separation ; aqueous two-phase system ; mass transport Obor OECD Chemical process engineering CEP GA20-09980S GA ČR - Grantová agentura ČR Způsob publikování Open access s časovým embargem (02.07.2024) Institucionální podpora UCHP-M - RVO:67985858 UT WOS 000855029400004 EID SCOPUS 85128280496 DOI 10.1016/j.seppur.2022.121050 Anotace Small-scale, continuous separation and purification of fine chemicals of pharmaceutical value represent a challenging engineering task. Currently available slug-flow and parallel-flow microfluidic extractors suffer from instabilities of the liquid-liquid interface and difficult realization of the counter-current arrangement. To tackle this challenge, we constructed a robust microfluidic membrane extractor, which was realized as a membrane tube-in-a-shell system operating in a wide range of extraction conditions. We tested the microextractor performance on separating 7-aminodeacetoxycephalosporanic acid (7-ADCA), an essential precursor of beta-lactam antibiotics. Aqueous two-phase system (ATPS) and a system of identical aqueous phases were used in a series of extraction experiments. Expectedly, we found that the counter-current arrangement provides an almost 100 % yield of 7-ADCA. The enhanced 7-ADCA enrichment anticipated in the selected ATPS thanks to favorable 7-ADCA partitioning was only reached at longer residence times. Lower mass transport resistances occurring in low viscous aqueous phases turned out to have a primary effect on the extraction characteristics. A detailed analysis of transport resistances also revealed that the contribution of the tubular membrane to the overall mass transport resistance is low. This important finding indicates that microcontactors with thin integrated membranes are a promising option for micro-or milli-plants when fine chemicals are continuously produced. Pracoviště Ústav chemických procesů Kontakt Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Rok sběru 2023 Elektronická adresa https://hdl.handle.net/11104/0334333
Počet záznamů: 1