Počet záznamů: 1
Incorporation of fibrin, platelets, and red blood cells into a coronary thrombus in time and space
- 1.0554916 - ÚMCH 2023 RIV DE eng J - Článek v odborném periodiku
Malý, M. - Riedel, Tomáš - Štikarová, J. - Suttnar, J. - Kotlín, R. - Hajsl, M. - Toušek, P. - Kaufmanová, J. - Kucerka, O. - Weisel, J. W. - Dyr, J. E.
Incorporation of fibrin, platelets, and red blood cells into a coronary thrombus in time and space.
Thrombosis and Haemostasis. Roč. 122, č. 3 (2022), s. 434-444. ISSN 0340-6245. E-ISSN 2567-689X
Grant CEP: GA ČR(CZ) GBP205/12/G118; GA ČR(CZ) GA19-02739S
Institucionální podpora: RVO:61389013
Klíčová slova: coronary * aspiration thrombectomy * scanning electron microscopy
Obor OECD: Hematology
Impakt faktor: 6.7, rok: 2022
Způsob publikování: Omezený přístup
https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0041-1739193
We describe the internal structure, spatial organization and dynamic formation of coronary artery thrombi from ST-segment elevation myocardial infarction patients. Scanning electron microscopy (SEM) revealed significant differences among four groups of patients (<2 hours, 2–6 hours, 6–12 hours, and >12 hours) related to the time of ischemia. Coronary artery thrombi from patients presenting less than 2 hours after the infarction were almost entirely composed of platelets, with small amounts of fibrin and red blood cells. In contrast, thrombi from late presenters (>12 hours) consisted of mainly platelets at the distal end, where clotting was initiated, with almost no platelets at the proximal end, while the red blood cell content went from low at the initiating end to more than 90% at the proximal end. Furthermore, fibrin was present mainly on the outside of the thrombi and older thrombi contained thicker fibers. The red blood cells in late thrombi were compressed to a close-packed, tessellated array of polyhedral structures, called polyhedrocytes. Moreover, there was redistribution from the originally homogeneous composition to fibrin and platelets to the outside, with polyhedrocytes on the interior. The presence of polyhedrocytes and the redistribution of components are signs of in vivo clot contraction (or retraction). These results suggest why later thrombi are resistant to fibrinolytic agents and other treatment modalities, since the close-packed polyhedrocytes form a nearly impermeable seal. Furthermore, it is of particular clinical significance that these findings suggest specific disparate therapies that will be most effective at different stages of thrombus development.
Trvalý link: http://hdl.handle.net/11104/0330724
Počet záznamů: 1