Počet záznamů: 1
Substituent effect of ring-substituted 3-hydroxynaphthalene-2-carboxanilides and 2-hydroxynaphthalene-1-carboxanilides in relation to their electrochemical and biological activity
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SYSNO ASEP 0546621 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Substituent effect of ring-substituted 3-hydroxynaphthalene-2-carboxanilides and 2-hydroxynaphthalene-1-carboxanilides in relation to their electrochemical and biological activity Tvůrce(i) Gajdar, J. (CZ)
Kos, J. (CZ)
Gonec, T. (CZ)
Brázdová, Marie (BFU-R) RID, ORCID
Soldanová, Zuzana (BFU-R) ORCID
Fojta, Miroslav (BFU-R) RID, ORCID
Jampílek, J. (SK)
Barek, J. (CZ)
Fischer, J. (CZ)Celkový počet autorů 9 Číslo článku 115667 Zdroj.dok. Journal of Electroanalytical Chemistry. - : Elsevier - ISSN 1572-6657
Roč. 899, OCT 15 2021 (2021)Poč.str. 8 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova herbicidal activity ; antioxidant activity ; antimycobacterial ; antibacterial ; agents Vědní obor RIV CG - Elektrochemie Obor OECD Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis) Způsob publikování Omezený přístup Institucionální podpora BFU-R - RVO:68081707 UT WOS 000702520400003 EID SCOPUS 85115117305 DOI 10.1016/j.jelechem.2021.115667 Anotace Two groups of novel anti-infective agents, 3-hydroxynaphthalene-2-carboxanilides and 2-hydroxynaphthalene-1-carboxanilides, were studied by voltammetric techniques at the glassy carbon electrode in aqueous media. Oxidation of hydroxyl group was observed for all forty-four studied compounds, all of them differentiated by a position and a substituent on the benzene moiety. A shift of the oxidation potential was observed for all cases based on electron-donating or electron-withdrawing properties of substituents. These shifts were successfully correlated with Hammett sigma substituent constants for meta- and para- substituted compounds. The observed differences in electrochemical behaviour (a shift of the oxidation potential of the unsubstituted compound, and the changes in the value of the reaction constant rho) between the two studied groups were highlighted and discussed. In addition, an attempt was made to correlate the electrochemical behaviour with the previously obtained in vitro anti-infective (antibacterial, antimycobacterial, antiprotozoal) activities and herbicidal activity. Due to the moderate activity only limited conclusions could be made. However, good relationships were observed between the oxidation potential and antitrypanosomal activities. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2022 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S1572665721006937?via%3Dihub
Počet záznamů: 1