Počet záznamů: 1
gamma-Tubulin Complexes and Fibrillar Arrays: Two Conserved High Molecular Forms with Many Cellular Functions
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SYSNO ASEP 0542216 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název gamma-Tubulin Complexes and Fibrillar Arrays: Two Conserved High Molecular Forms with Many Cellular Functions Tvůrce(i) Chumová, Jana (MBU-M)
Kourová, Hana (MBU-M)
Trögelová, Lucie (MBU-M) ORCID
Daniel, G. (SE)
Binarová, Pavla (MBU-M) RID, ORCIDČíslo článku 776 Zdroj.dok. Cells. - : MDPI
Roč. 10, č. 4 (2021)Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova microtubules ; plants ; gamma-tubulin ; gamma-tubulin complexes ; fibrillar arrays ; nucleation ; signaling ; sequestration Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Cell biology Způsob publikování Open access Institucionální podpora MBU-M - RVO:61388971 UT WOS 000642853900001 EID SCOPUS 85105212260 DOI 10.3390/cells10040776 Anotace Higher plants represent a large group of eukaryotes where centrosomes are absent. The functions of gamma-tubulin small complexes (gamma-TuSCs) and gamma-tubulin ring complexes (gamma-TuRCs) in metazoans and fungi in microtubule nucleation are well established and the majority of components found in the complexes are present in plants. However, plant microtubules are also nucleated in a gamma-tubulin-dependent but gamma-TuRC-independent manner. There is growing evidence that gamma-tubulin is a microtubule nucleator without being complexed in gamma-TuRC. Fibrillar arrays of gamma-tubulin were demonstrated in plant and animal cells and the ability of gamma-tubulin to assemble into linear oligomers/polymers was confirmed in vitro for both native and recombinant gamma-tubulin. The functions of gamma-tubulin as a template for microtubule nucleation or in promoting spontaneous nucleation is outlined. Higher plants represent an excellent model for studies on the role of gamma-tubulin in nucleation due to their acentrosomal nature and high abundancy and conservation of gamma-tubulin including its intrinsic ability to assemble filaments. The defining scaffolding or sequestration functions of plant gamma-tubulin in microtubule organization or in nuclear processes will help our understanding of its cellular roles in eukaryotes. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2022 Elektronická adresa https://www.mdpi.com/2073-4409/10/4/776
Počet záznamů: 1