Počet záznamů: 1  

Structure-to-efficacy relationship of HPMA-based nanomedicines: the tumor spheroid penetration study

  1. 1.
    SYSNO ASEP0536604
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevStructure-to-efficacy relationship of HPMA-based nanomedicines: the tumor spheroid penetration study
    Tvůrce(i) Kudláčová, Júlia (UMCH-V) RID, ORCID
    Kotrchová, Lenka (UMCH-V) RID, ORCID
    Kostka, Libor (UMCH-V) RID, ORCID
    Randárová, Eva (UMCH-V) RID
    Filipová, Marcela (UMCH-V) RID, ORCID
    Janoušková, Olga (UMCH-V) RID, SAI, ORCID
    Fang, J. (JP)
    Etrych, Tomáš (UMCH-V) RID, ORCID
    Číslo článku1242
    Zdroj.dok.Pharmaceutics. - : MDPI
    Roč. 12, č. 12 (2020), s. 1-15
    Poč.str.15 s.
    Jazyk dok.eng - angličtina
    Země vyd.CH - Švýcarsko
    Klíč. slovaHPMA polymers ; pirarubicin ; tumor spheroids
    Vědní obor RIVCD - Makromolekulární chemie
    Obor OECDPolymer science
    CEPLTAUSA18083 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
    GA19-01417S GA ČR - Grantová agentura ČR
    Způsob publikováníOpen access
    Institucionální podporaUMCH-V - RVO:61389013
    UT WOS000602306000001
    EID SCOPUS85098233087
    DOI10.3390/pharmaceutics12121242
    AnotaceNanomedicines are a novel class of therapeutics that benefit from the nano dimensions of the drug carrier. These nanosystems are highly advantageous mainly within cancer treatment due to their enhanced tumor accumulation. Monolayer tumor cells frequently used in routine preclinical assessment of nanotherapeutics do not have a spatial structural architecture that allows the investigation of the penetration of nanomedicines to predict their behavior in real tumor tissue. Therefore, tumor spheroids from colon carcinoma C26 cells and glioblastoma U87-MG cells were used as 3D in vitro models to analyze the effect of the inner structure, hydrodynamic size, dispersity, and biodegradability of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-based nanomedicines carrying anticancer drug pirarubicin (THP) on the penetration within spheroids. While almost identical penetration through spheroids of linear and star-like copolymers and also their conjugates with THP was observed, THP penetration after nanomedicines application was considerably deeper than for the free THP, thus proving the benefit of polymer carriers. The cytotoxicity of THP-polymer nanomedicines against tumor cell spheroids was almost identical as for the free THP, whereas the 2D cell cytotoxicity of these nanomedicines is usually lower. The nanomedicines thus proved the enhanced efficacy within the more realistic 3D tumor cell spheroid system.
    PracovištěÚstav makromolekulární chemie
    KontaktEva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
    Rok sběru2021
    Elektronická adresahttps://www.mdpi.com/1999-4923/12/12/1242
Počet záznamů: 1  

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