Počet záznamů: 1
Stability of psilocybin and its four analogs in the biomass of the psychotropic mushroom Psilocybe cubensis
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SYSNO ASEP 0536518 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Stability of psilocybin and its four analogs in the biomass of the psychotropic mushroom Psilocybe cubensis Tvůrce(i) Gotvaldová, K. (CZ)
Hájková, K. (CZ)
Borovička, Jan (UJF-V) RID, ORCID, SAI
Jurok, R. (CZ)
Cihlářová, P. (CZ)
Kuchař, M. (CZ)Celkový počet autorů 6 Zdroj.dok. Drug Testing and Analysis. - : Wiley - ISSN 1942-7603
Roč. 13, č. 2 (2021), s. 439-446Poč.str. 8 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova LC-MS ; mushrooms ; psilocybin ; stability ; tryptamines Vědní obor RIV CB - Analytická chemie, separace Obor OECD Analytical chemistry Způsob publikování Omezený přístup Institucionální podpora UJF-V - RVO:61389005 UT WOS 000585171500001 EID SCOPUS 85096679307 DOI 10.1002/dta.2950 Anotace Psilocybin, psilocin, baeocystin, norbaeocystin, and aeruginascin are tryptamines structurally similar to the neurotransmitter serotonin. Psilocybin and its pharmacologically active metabolite psilocin in particular are known for their psychoactive effects. These substances typically occur in most species of the genus Psilocybe (Fungi, Strophariaceae). Even the sclerotia of some of these fungi known as 'magic truffles' are of growing interest in microdosing due to them improving cognitive function studies. In addition to microdosing studies, psilocybin has also been applied in clinical studies, but only its pure form has been administrated so far. Moreover, the determination of tryptamine alkaloids is used in forensic analysis.
In this study, freshly cultivated fruit bodies of Psilocybe cubensis were used for monitoring stability (including storage and processing conditions of fruiting bodies). Furthermore, mycelium and the individual parts of the fruiting bodies (caps, stipes, and basidiospores) were also examined. The concentration of tryptamines in final extracts was analyzed using ultra-high-performance liquid chromatography coupled with mass spectrometry. No tryptamines were detected in the basidiospores, and only psilocin was present at 0.47 wt.% in the mycelium. The stipes contained approximately half the amount of tryptamine alkaloids (0.52 wt.%) than the caps (1.03 wt.%). However, these results were not statistically significant, as the concentration of tryptamines in individual fruiting bodies is highly variable. The storage conditions showed that the highest degradation of tryptamines was seen in fresh mushrooms stored at -80 degrees C, and the lowest decay was seen in dried biomass stored in the dark at room temperature.Pracoviště Ústav jaderné fyziky Kontakt Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228 Rok sběru 2022 Elektronická adresa https://doi.org/10.1002/dta.2950
Počet záznamů: 1