Počet záznamů: 1  

Stability of psilocybin and its four analogs in the biomass of the psychotropic mushroom Psilocybe cubensis

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    SYSNO ASEP0536518
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevStability of psilocybin and its four analogs in the biomass of the psychotropic mushroom Psilocybe cubensis
    Tvůrce(i) Gotvaldová, K. (CZ)
    Hájková, K. (CZ)
    Borovička, Jan (UJF-V) RID, ORCID, SAI
    Jurok, R. (CZ)
    Cihlářová, P. (CZ)
    Kuchař, M. (CZ)
    Celkový počet autorů6
    Zdroj.dok.Drug Testing and Analysis. - : Wiley - ISSN 1942-7603
    Roč. 13, č. 2 (2021), s. 439-446
    Poč.str.8 s.
    Forma vydáníTištěná - P
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovaLC-MS ; mushrooms ; psilocybin ; stability ; tryptamines
    Vědní obor RIVCB - Analytická chemie, separace
    Obor OECDAnalytical chemistry
    Způsob publikováníOmezený přístup
    Institucionální podporaUJF-V - RVO:61389005
    UT WOS000585171500001
    EID SCOPUS85096679307
    DOI10.1002/dta.2950
    AnotacePsilocybin, psilocin, baeocystin, norbaeocystin, and aeruginascin are tryptamines structurally similar to the neurotransmitter serotonin. Psilocybin and its pharmacologically active metabolite psilocin in particular are known for their psychoactive effects. These substances typically occur in most species of the genus Psilocybe (Fungi, Strophariaceae). Even the sclerotia of some of these fungi known as 'magic truffles' are of growing interest in microdosing due to them improving cognitive function studies. In addition to microdosing studies, psilocybin has also been applied in clinical studies, but only its pure form has been administrated so far. Moreover, the determination of tryptamine alkaloids is used in forensic analysis.

    In this study, freshly cultivated fruit bodies of Psilocybe cubensis were used for monitoring stability (including storage and processing conditions of fruiting bodies). Furthermore, mycelium and the individual parts of the fruiting bodies (caps, stipes, and basidiospores) were also examined. The concentration of tryptamines in final extracts was analyzed using ultra-high-performance liquid chromatography coupled with mass spectrometry. No tryptamines were detected in the basidiospores, and only psilocin was present at 0.47 wt.% in the mycelium. The stipes contained approximately half the amount of tryptamine alkaloids (0.52 wt.%) than the caps (1.03 wt.%). However, these results were not statistically significant, as the concentration of tryptamines in individual fruiting bodies is highly variable. The storage conditions showed that the highest degradation of tryptamines was seen in fresh mushrooms stored at -80 degrees C, and the lowest decay was seen in dried biomass stored in the dark at room temperature.
    PracovištěÚstav jaderné fyziky
    KontaktMarkéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228
    Rok sběru2022
    Elektronická adresahttps://doi.org/10.1002/dta.2950
Počet záznamů: 1  

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