Počet záznamů: 1
Tissue Rebuilding During Spontaneous Regression of Melanoma in the Melanoma-bearing Libechov Minipig
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SYSNO ASEP 0499609 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Tissue Rebuilding During Spontaneous Regression of Melanoma in the Melanoma-bearing Libechov Minipig Tvůrce(i) Plánská, Daniela (UZFG-Y)
Kovalská, Jana (UZFG-Y) RID
Čížková, Jana (UZFG-Y)
Horák, Vratislav (UZFG-Y) RID, ORCIDZdroj.dok. Anticancer Research. - : International Institute of Anticancer Research - ISSN 0250-7005
Roč. 38, č. 8 (2018), s. 4629-4636Poč.str. 8 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. GR - Řecko Klíč. slova fibronectin ; tenasin C ; MMP-2 Vědní obor RIV FD - Onkologie a hematologie Obor OECD Oncology CEP LO1609 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy ED2.1.00/03.0124 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UZFG-Y - RVO:67985904 UT WOS 000449948300027 EID SCOPUS 85050801728 DOI 10.21873/anticanres.12767 Anotace Background/Aim: Melanoma is a cancer disease with increasing incidence in the Caucasian population. It is often accompanied by spontaneous regression (SR), probably due to high immunogenicity. Understanding of this phenomenon could allow its induction in clinical practice, but detailed study in humans is impossible for ethical reasons. The aim of this study was to determine the role of fibronectin, tenascin C, and MMP-2 in the process of SR. Materials and Methods: Time-lapse study of SR was performed in the MeLiM (Melanoma-bearing Libechov Minipig) model. Skin melanomas were taken from 3 weeks to 8 months of age and immunohistochemically processed for fibronectin, tenascin C and matrix metalloproteinase-2 (MMP-2). Results: Expression of all studied proteins increased up to the 10th week of age. Two structurally different areas were distinguishable from the 3rd month of age. MPP-2 expression predominated in areas with melanoma cells, whereas fibronectin and tenascin-C prevailed in the forming fibrous tissue. Conclusion: Rebuilding of melanoma into the fibrous tissue during SR was connected with a general rise in fibronectin and tenascin C expression. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2019
Počet záznamů: 1