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The nanoscaled metal-organic framework ICR-2 as a carrier of porphyrins for photodynamic therapy
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SYSNO ASEP 0497329 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The nanoscaled metal-organic framework ICR-2 as a carrier of porphyrins for photodynamic therapy Tvůrce(i) Hynek, Jan (UACH-T) SAI, RID, ORCID
Jurík, S. (CZ)
Koncošová, M. (CZ)
Zelenka, J. (CZ)
Křížová, I. (CZ)
Ruml, T. (CZ)
Kirakci, Kaplan (UACH-T) SAI, RID, ORCID
Jakubec, Ivo (UACH-T) SAI, RID, ORCID
Kovanda, F. (CZ)
Lang, Kamil (UACH-T) SAI, RID, ORCID
Demel, Jan (UACH-T) SAI, RID, ORCIDZdroj.dok. Beilstein Journal of Nanotechnology. - : Beilstein - Institut zur Foerderung der Chemischen Wissenschaften - ISSN 2190-4286
Roč. 9, NOV (2018), s. 2960-2967Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova metal-organic framework ; phosphinic acid based MOF ; photodynamic therapy ; porphyrin ; singlet oxygen Vědní obor RIV CA - Anorganická chemie Obor OECD Inorganic and nuclear chemistry CEP GA16-02098S GA ČR - Grantová agentura ČR Institucionální podpora UACH-T - RVO:61388980 UT WOS 000451826500001 EID SCOPUS 85058219824 DOI 10.3762/bjnano.9.275 Anotace Nanosized porphyrin-containing metal-organic frameworks (MOFs) attract considerable attention as solid-state photosensitizers for biological applications. In this study, we have for the first time synthesised and characterised phosphinate-based MOF nanoparticles, nanoICR-2 (Inorganic Chemistry Rez). We demonstrate that nanoICR-2 can be decorated with anionic 5,10,15,20-tetrakis(4-
R-phosphinatophenyl)porphyrins (R = methyl, isopropyl, phenyl) by utilizing unsaturated metal sites on the nanoparticle surface. The use of these porphyrins allows for superior loading of the nanoparticles when compared with commonly used 5,10,15,20-tetrakis(4-arboxyphenyl)porphyrin. The nanoICR-2/porphyrin composites retain part of the free porphyrins photophysical properties, while the photodynamic efficacy is strongly affected by the R substituent at the porphyrin phosphinate groups. Thus, phosphinatophenylporphyrin with phenyl substituents has the strongest photodynamic efficacy due to the most efficient cellular uptake.
Pracoviště Ústav anorganické chemie Kontakt Jana Kroneislová, krone@iic.cas.cz, Tel.: 311 236 931 Rok sběru 2019
Počet záznamů: 1