Počet záznamů: 1
Phosphonium Carbosilane Dendrimers - Interaction with a Simple Biological Membrane Model.
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SYSNO ASEP 0492064 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Phosphonium Carbosilane Dendrimers - Interaction with a Simple Biological Membrane Model. Tvůrce(i) Wróbel, D. (CZ)
Kubíková, R. (CZ)
Müllerová, Monika (UCHP-M) RID, ORCID, SAI
Strašák, Tomáš (UCHP-M) RID, ORCID, SAI
Růžička, K. (CZ)
Fulem, M. (CZ)
Malý, J. (CZ)Zdroj.dok. Physical Chemistry Chemical Physics. - : Royal Society of Chemistry - ISSN 1463-9076
Roč. 20, č. 21 (2018), s. 14753-14764Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova lipid-bilayer disruption ; blood-cell ghosts ; panam dendrimers Vědní obor RIV ED - Fyziologie Obor OECD Physiology (including cytology) CEP GA15-05903S GA ČR - Grantová agentura ČR Institucionální podpora UCHP-M - RVO:67985858 UT WOS 000434246300046 EID SCOPUS 85048004453 DOI 10.1039/C7CP07237F Anotace The influence of three generations of five different phosphonium carbosilane dendrimers and one ammonium carbosilane dendrimer as a reference (PMe3, PBu3, P(Et-2)(2)(CH2)(3)OH, PPh3, P(MeOPh)(3) and NMe3, peripheral functional groups) on dimyristoylphosphatidylcholine (DMPC) or a lipid mixture dimyristoylphosphatidylcholine/dimyristoylphosphatidylglycerol (DMPC/DMPG) of liposomes was studied by fluorescence polarization measurements and differential scanning calorimetry. All types of dendrimers interacted with neutral as well as negatively charged liposomes, but the strength and observed influence were different. Concentration, type of peripheral functional group modification and dendrimer generation were the main factors influencing the interaction. Generally, weak interactions as well as destabilization of the lipid membranes at low concentrations, regardless of liposome type, were observed in the case of DmPMe(3), DmNMe(3), DmPBu(3) and DmP(Et-2)(2)(CH2)(3)OH. Dendrimers with PPh3 and P(MeOPh)(3) peripheral functional groups interacted much more strongly and increased the rigidity of liposomes. Electrostatic interactions, the hydrophobicity of substituents and charge shielding on the peripheral phosphonium group are important factors in the interaction. We suggest that, among the other types of dendrimers, the dendrimer with the P(MeOPh)(3) peripheral functional group is a highly promising candidate for the design of a drug delivery system due to its positive charge, efficient interaction with lipidic membranes and low cytotoxicity. Pracoviště Ústav chemických procesů Kontakt Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Rok sběru 2019
Počet záznamů: 1