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LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis
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SYSNO ASEP 0469444 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis Tvůrce(i) Česneková, J. (CZ)
Spáčilová, J. (CZ)
Hansíková, H. (CZ)
Houštěk, Josef (FGU-C) RID, ORCID
Zeman, J. (CZ)
Stibůrek, L. (CZ)Zdroj.dok. OncoTarget. - : Impact Journals LLC - ISSN 1949-2553
Roč. 7, č. 30 (2016), s. 47687-47698Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova p53 ; LACE1 ; mitochondria ; apoptosis ; translocation Vědní obor RIV EB - Genetika a molekulární biologie CEP GA13-07223S GA ČR - Grantová agentura ČR Institucionální podpora FGU-C - RVO:67985823 UT WOS 000385413000067 EID SCOPUS 84982836612 DOI https://doi.org/10.18632/oncotarget.9959 Anotace p53 is a major cellular tumor suppressor that in addition to its nuclear, transcription-dependent activity is also known to function extranuclearly. Cellular stressors such as reactive oxygen species can promote translocation of p53 into mitochondria where it acts to protect mitochondrial genome or trigger cell death via transcription-independent manner. Here we report that the mammalian homologue of yeast mitochondrial Afg1 ATPase (LACE1) promotes translocation of p53 into mitochondria. We further show that LACE1 exhibits significant pro-apoptotic activity, which is dependent on p53, and that the protein is required for normal mitochondrial respiratory function. LACE1 physically interacts with p53 and is necessary for mitomycin c-induced translocation of p53 into mitochondria. Conversely, increased expression of LACE1 partitions p53 to mitochondria, causes reduction in nuclear p53 content and induces apoptosis. Thus, LACE1 mediates mitochondrial translocation of p53 and its transcription-independent apoptosis. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2017
Počet záznamů: 1