Translation in the mammalian oocyte in space and time

0459927 - ÚŽFG 2017 RIV DE eng J - Článek v odborném periodiku
Šušor, Andrej - Jansová, Denisa - Anger, Martin - Kubelka, Michal
Translation in the mammalian oocyte in space and time.
Cell and Tissue Research. Roč. 363, č. 1 (2016), s. 69-84. ISSN 0302-766X. E-ISSN 1432-0878
Grant CEP: GA ČR GA13-12291S; GA ČR GA15-22765S; GA ČR GAP502/12/2201
Institucionální podpora: RVO:67985904
Klíčová slova: oocyte * translation * RNA
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 2.787, rok: 2016

A hallmark of oocyte development in mammals is the dependence on the translation and utilization of stored RNA and proteins rather than the de novo transcription of genes in order to sustain meiotic progression and early embryo development. In the absence of transcription, the completion of meiosis and early embryo development in mammals relies significantly on maternally synthesized RNAs. Posttranscriptional control of gene expression at the translational level has emerged as an important cellular function in normal development. Therefore, the regulation of gene expression in oocytes is controlled almost exclusively at the level of mRNA and protein stabilization and protein synthesis. This current review is focused on the recently emerged findings on RNA distribution related to the temporal and spatial translational control of the meiotic progression of the mammalian oocyte.
Trvalý link: http://hdl.handle.net/11104/0260086