Počet záznamů: 1
Mast cell chemotaxis - chemoattractants and signaling pathways
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SYSNO ASEP 0386049 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Mast cell chemotaxis - chemoattractants and signaling pathways Tvůrce(i) Hálová, Ivana (UMG-J) RID, ORCID
Dráberová, Lubica (UMG-J) RID
Dráber, Petr (UMG-J) RIDZdroj.dok. Frontiers in Immunology. - : Frontiers Media - ISSN 1664-3224
Roč. 3, May (2012), s. 119Poč.str. 19 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova mast cell ; IgE receptor ; plasma membrane Vědní obor RIV EB - Genetika a molekulární biologie CEP LD12073 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA301/09/1826 GA ČR - Grantová agentura ČR GAP302/10/1759 GA ČR - Grantová agentura ČR Institucionální podpora UMG-J - RVO:68378050 DOI 10.3389/fimmu.2012.00119 Anotace Migration of mast cells is essential for their recruitment within target tissues where they play an important role in innate and adaptive immune responses. These processes rely on the ability of mast cells to recognize appropriate chemotactic stimuli and react to them by a chemotactic response. Another level of intercellular communication is attained by production of chemoattractants by activated mast cells, which results in accumulation of mast cells and other hematopoietic cells at the sites of inflammation. Mast cells express numerous surface receptors for various ligands with properties of potent chemoattractants. They include the stem cell factor (SCF) recognized by c-Kit, antigen, which binds to immunoglobulin E (IgE) anchored to the high affinity IgE receptor (FcεRI), highly cytokinergic (HC) IgE recognized by FcεRI, lipid mediator sphingosine-1-phosphate (S1P), which binds to G protein-coupled receptors (GPCRs). Other large groups of chemoattractants are eicosanoids [prostaglandin E(2) and D(2), leukotriene (LT) B(4), LTD(4), and LTC(4), and others] and chemokines (CC, CXC, C, and CX3C), which also bind to various GPCRs. Further noteworthy chemoattractants are isoforms of transforming growth factor (TGF) β1-3, which are sensitively recognized by TGF-β serine/threonine type I and II β receptors, adenosine, C1q, C3a, and C5a components of the complement, 5-hydroxytryptamine, neuroendocrine peptide catestatin, tumor necrosis factor-α, and others. Here we discuss the major types of chemoattractants recognized by mast cells, their target receptors, as well as signaling pathways they utilize. We also briefly deal with methods used for studies of mast cell chemotaxis and with ways of how these studies profited from the results obtained in other cellular systems. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2013
Počet záznamů: 1