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Cytotoxicity evaluation of photosensitizer-conjugated hexagonal upconverting nanoparticles
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SYSNO ASEP 0571345 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Cytotoxicity evaluation of photosensitizer-conjugated hexagonal upconverting nanoparticles Tvůrce(i) Nahorniak, Mykhailo (UMCH-V) RID
Oleksa, Viktoriia (UMCH-V) RID
Vasylyshyn, Taras (UMCH-V) RID
Pop-Georgievski, Ognen (UMCH-V) RID, ORCID
Rydvalová, Eliška (UMCH-V) ORCID
Filipová, Marcela (UMCH-V) RID, ORCID
Horák, Daniel (UMCH-V) RID, ORCIDČíslo článku 1535 Zdroj.dok. Nanomaterials. - : MDPI
Roč. 13, č. 9 (2023)Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova upcoverting ; nanoparticles ; rose bengal Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP GA21-04420S GA ČR - Grantová agentura ČR LX22NPO5102 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000987079700001 EID SCOPUS 85159196892 DOI 10.3390/nano13091535 Anotace In this report, we synthesized hexagonal NaYF4:Yb,Er upconverting nanoparticles (UCNPs) of 171 nm in size with a narrow particle size distribution. To address their colloidal stabi-lity in aqueous media and to incorporate a photosensitizer that can produce reactive singlet oxygen (1O2) to kill tumor cells, UCNPs were conjugated with 6-bromohexanoic acid-functionalized Rose Bengal (RB) and coated with PEG-alendronate (PEG-Ale). The particles were thoroughly characterized by transmission electron microscopy, dynamic light scattering, ATR FTIR, X-ray photoelectron spectroscopy, thermogravimetric analysis, and spectrofluorometry, and 1O2 formation was detected using a 9,10-diphenylanthracene spectrophotometric probe. Cytotoxicity determination on rat mesenchymal stem cells by using the MTT assay showed that neutralization of the large positive surface charge of neat UCNPs with PEG-Ale and the bound RB sensitizer significantly reduced the concentration-dependent cytotoxicity. The presented strategy shows great potential for the use of these particles as a novel agent for the photodynamic therapy of tumors. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2024 Elektronická adresa https://www.mdpi.com/2079-4991/13/9/1535
Počet záznamů: 1