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Telomerase as a possible key to bypass reproductive cost
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SYSNO ASEP 0568472 Druh ASEP J - Článek v odborném periodiku Zařazení RIV O - Ostatní Poddruh J Článek ve WOS Název Telomerase as a possible key to bypass reproductive cost Tvůrce(i) Čapková Frydrychová, Radmila (BC-A) RID, ORCID Zdroj.dok. Molecular Ecology. - : Wiley - ISSN 0962-1083
Roč. 32, č. 9 (2023), s. 2134-2143Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova ageing ; cost of reproduction ; reproduction strategy Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Reproductive biology (medical aspects to be 3) Způsob publikování Open access Institucionální podpora BC-A - RVO:60077344 UT WOS 000959131600001 EID SCOPUS 85147930051 DOI 10.1111/mec.16870 Anotace Three widely accepted assumptions are based on telomere research in human cells: (i) telomere length is a determinant of replicative ageing, (ii) telomerase activity in somatic cells supports the proliferative capacity of the cells and thus contributes to their regenerative potential and is a determinant of organismal lifespan, and (iii) the lack of telomerase activity acts as a tumour suppression mechanism. However, from a broader view, the link between telomere biology and cellular and organismal ageing, as well as tumour development, remains of debate, as I demonstrate with numerous examples of invertebrate and vertebrate species. Consequently, I propose a novel hypothesis that telomere biology, via somatic telomerase activity, reflects ageing rate from the perspective of species reproduction strategy. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2024 Elektronická adresa https://onlinelibrary.wiley.com/doi/epdf/10.1111/mec.16870
Počet záznamů: 1