Počet záznamů: 1
Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration
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SYSNO ASEP 0561635 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration Tvůrce(i) Fialova, J. L. (CZ)
Hönigová, K. (CZ)
Raudenská, M. (CZ)
Miksatkova, L. (CZ)
Zobalová, Renata (BTO-N) RID
Navrátil, J. (CZ)
Smigova, Jana (BTO-N)
Moturu, T. R. (BE)
Vicar, T. (CZ)
Balvan, J. (CZ)
Veselá, K. (CZ)
Abramenko, N. (CZ)
Kejik, Z. (CZ)
Kaplánek, R. (CZ)
Gumulec, J. (CZ)
Rosel, D. (CZ)
Martásek, P. (CZ)
Brabek, J. (CZ)
Jakubek, M. (CZ)
Neužil, Jiří (BTO-N) RID
Masarik, M. (CZ)Celkový počet autorů 21 Číslo článku 113582 Zdroj.dok. Biomedicine & Pharmacotherapy. - : Elsevier - ISSN 0753-3322
Roč. 154, OCT 2022 (2022)Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. FR - Francie Klíč. slova Dihydroorotate dehydrogenase ; Metastasis ; Mitochondria ; Migration ; Pentamethinium salts Vědní obor RIV FR - Farmakologie a lékárnická chemie Obor OECD Pharmacology and pharmacy Způsob publikování Open access Institucionální podpora BTO-N - RVO:86652036 UT WOS 000855198000002 EID SCOPUS 85137077593 DOI 10.1016/j.biopha.2022.113582 Anotace Mitochondria generate energy and building blocks required for cellular growth and function. The notion that mitochondria are not involved in the cancer growth has been challenged in recent years together with the emerging idea of mitochondria as a promising therapeutic target for oncologic diseases. Pentamethinium salts, cyan dyes with positively charged nitrogen on the benzothiazole or indole part of the molecule, were originally designed as mitochondrial probes. In this study, we show that pentamethinium salts have a strong effect on mitochondria, suppressing cancer cell proliferation and migration. This is likely linked to the strong inhibitory effect of the salts on dihydroorotate dehydrogenase (DHODH)-dependent respiration that has a key role in the de novo pyrimidine synthesis pathway. We also show that pentamethinium salts cause oxidative stress, redistri-bution of mitochondria, and a decrease in mitochondria mass. In conclusion, pentamethinium salts present novel anti-cancer agents worthy of further studies. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2023 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0753332222009714?via%3Dihub
Počet záznamů: 1