Počet záznamů: 1
Longitudinal evidence for immunosenescence and inflammaging in free-living great tits
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SYSNO ASEP 0545282 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Longitudinal evidence for immunosenescence and inflammaging in free-living great tits Tvůrce(i) Těšický, M. (CZ)
Krajzingrová, T. (CZ)
Świderská, Z. (CZ)
Syslová, K. (CZ)
Bílková, B. (CZ)
Eliáš, J. (CZ)
Velová, H. (CZ)
Svobodová, J. (CZ)
Bauerová, P. (CZ)
Albrecht, Tomáš (UBO-W) RID, SAI, ORCID
Vinkler, M. (CZ)Celkový počet autorů 11 Číslo článku 111527 Zdroj.dok. Experimental Gerontology. - : Elsevier - ISSN 0531-5565
Roč. 154, October (2021)Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Aging ; Ageing ; Birds ; Ecoimmunology ; Haematology ; Immunosenescence ; Innate immunity senescence ; Inflammation ; Respiratory burst ; Oxidative burst ; Oxidative damage ; Oxidative stress ; Passerines ; Redox balance ; Avian inflammaging ; Testosterone ; Wild Vědní obor RIV EG - Zoologie Obor OECD Ornithology CEP GA15-11782S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora UBO-W - RVO:68081766 UT WOS 000697723500007 EID SCOPUS 85114095516 DOI 10.1016/j.exger.2021.111527 Anotace The first-line effector mechanisms of immune defence, including inflammation and oxidative burst, contribute significantly to host-pathogen resistance. Whether these immune responses undergo age-related changes in birds remains unknown. Here, we tracked selected inflammatory parameters in 54 free-living great tits (Parus major) of known age, captured repeatedly over three consecutive years, with the aims to investigate long-term repeatability and age-dependent changes in cellular oxidative burst responsiveness upon in vitro stimulation with bacterial lipopolysaccharide (LPS), and to identify its relationships with leukotriene B4 (LTB4) levels and haematological traits. In addition, we linked these immunological traits to selected physiological markers (antioxidants and oxidative stress markers). LTB4 levels increased with age and we have shown a similar non-significant tendency also for absolute granulocyte counts, indicating propagating chronic inflammation over the bird's lifetime, consistent with the inflammaging hypothesis. In contrast, cellular oxidative burst followed a quadratic trend of dependency on age with a peak in midlife individuals, in line with the immunosenescence hypothesis. Interestingly, LTB4 levels were positively associated with general oxidative damage, but negatively with antioxidant glutathione peroxidase activity, indicating links to redox balance. This longitudinal study demonstrates the contrasting patterns of age-related changes in background and acute markers of pro-inflammatory immunity contributing to immunosenescence in birds and thus provides basis for interpretation of the tested inflammatory markers in cross-cohort datasets. Pracoviště Ústav biologie obratlovců Kontakt Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Rok sběru 2022 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0531556521003090?via%3Dihub
Počet záznamů: 1