Počet záznamů: 1
Microcomputed tomographic, biomechanical and histological analyses of lumbar interbody fusion with iliac crest bone graft in a pig model
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SYSNO ASEP 0542711 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Microcomputed tomographic, biomechanical and histological analyses of lumbar interbody fusion with iliac crest bone graft in a pig model Tvůrce(i) Krtička, M. (CZ)
Nekuda, V. (CZ)
Ira, D. (CZ)
Sedláček, R. (CZ)
Suchý, Tomáš (USMH-B) RID, ORCID, SAI
Kavková, M. (CZ)
Břínek, A. (CZ)
Göpfrt, E. (CZ)
Bilik, A. (CZ)
Kaiser, J. (CZ)
Křen, L. (CZ)
Plánka, L. (CZ)Celkový počet autorů 12 Zdroj.dok. Acta veterinaria Brno. - : Veterinární a farmaceutická univerzita Brno - ISSN 0001-7213
Roč. 90, č. 1 (2021), s. 69-75Poč.str. 7 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova Bone replacement ; Injury ; Spine Vědní obor RIV FI - Traumatologie, ortopedie Obor OECD Medical engineering Způsob publikování Open access Institucionální podpora USMH-B - RVO:67985891 UT WOS 000654628800009 EID SCOPUS 85104823198 DOI 10.2754/avb202190010069 Anotace The main goal of this study was to assess the progress of vertebral stability after lumbar interbody fusion related to microcomputed tomography (micro CT), biomechanical analysis, and histological assessment towards spine fusion. Twelve male pigs were used, each underwent L2-3 discectomy and implantation of an iliac crest bone graft in two groups, six spines were harvested eight weeks (A1) and six spines 16 weeks (A2) after surgery (7 native spines for biomechanical analysis). The CT was performed by GE phoenix datos|x 2.0 with a sample drift correction. The samples were divided according to fusion quality. Biomechanical evaluation was carried out on the MTS Mini Bionix testing system. In the nondestructive mode, three cycles of pure bending moments were applied (5 Nm load limit) at a rate of 20 °/min in flexion (+40 °) and extension (-40 °). Two representative histological sections from four samples were obtained (A1, n = 2, A2, n = 2), areas of mature bone were quantified. In micro CT, better results were achieved in group A2 (not significant). Eight weeks after the operation, flexural stiffness decreased to 48% of its initial value for native cadavers (P < 0.05), after 16 weeks it was comparable to native cadavers, demonstrating the suitability of the implanted graft (P < 0.05). The newly formed bone tissue occupied an average area of 94.205 mm (A1) and 26.240 mm (A2). It was confirmed that micro CT, biomechanical analysis, and histological assessment are technically feasible and suitable for the evaluation of results of other methods of large bone defect treatment. 2 2 Pracoviště Ústav struktury a mechaniky hornin Kontakt Iva Švihálková, svihalkova@irsm.cas.cz, Tel.: 266 009 216 Rok sběru 2022 Elektronická adresa https://actavet.vfu.cz/90/1/0069/
Počet záznamů: 1