Control of oxidative stress in Jurkat cells as a model of leukemia treatment

0541846 - FZÚ 2022 RIV NL eng J - Článek v odborném periodiku
Pshenichnikov, S. - Omelyanchik, A. - Efremova, M. - Lunova, Mariia - Gazatova, N. - Malashchenko, V. - Khaziakhmatova, O. - Litvinova, L. - Perov, N. - Panina, L. - Peddis, D. - Lunov, Oleg - Rodionova, V. - Levada, K.
Control of oxidative stress in Jurkat cells as a model of leukemia treatment.
Journal of Magnetism and Magnetic Materials. Roč. 523, April (2021), č. článku 167623. ISSN 0304-8853. E-ISSN 1873-4766
Grant CEP: GA MŠMT(CZ) EF16_019/0000760
Grant ostatní: OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institucionální podpora: RVO:68378271
Klíčová slova: magnetic nanoparticles * cytotoxicity * PBMC * jurkat * leukemia * magnetic fields
Obor OECD: Biophysics
Impakt faktor: 3.097, rok: 2021
Způsob publikování: Omezený přístup
https://doi.org/10.1016/j.jmmm.2020.167623

This paper describes proof-of-concept for antileukemia treatment based on the reactive oxygen species (ROS) induction supplemented with magnetic nanoparticles in the presence of moderate-intensity magnetic fields. The T-lymphoblastic leukemia cell line (Jurkat) was chosen as an in vitro model of acute lymphoblastic leukemia. The elevated ROS levels were generated by iron oxide magnetic nanoparticles. We found an enhanced cytotoxic effect of magnetic nanoparticles in the presence of a magnetic field on cancerous Jurkat cell line due to induced oxidative stress after cultivation in magnetic fields with an average strength of 0.26–0.36 T and the field spatial gradient up to 100 T/m. At the same conditions of nanoparticles intake, the viability of human peripheral blood mononuclear cells (model of healthy cells) was not inhibited. Thus, we demonstrated the feasibility of antileukemia treatment by magnetic nanoparticles controlled by a magnetic field.
Trvalý link: http://hdl.handle.net/11104/0319357