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Structural characteristics and biological effects of exopolysaccharide produced by cyanobacterium Nostoc sp
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SYSNO ASEP 0532233 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Structural characteristics and biological effects of exopolysaccharide produced by cyanobacterium Nostoc sp Tvůrce(i) Uhliariková, I. (SK)
Šutovská, M. (SK)
Barboríková, J. (SK)
Molitorisová, M. (SK)
Kim, H. J. (KR)
Park, Y. I. (KR)
Matulová, M. (SK)
Lukavský, Jaromír (BU-J) RID, ORCID
Hromadková, Z. (SK)
Capek, P. (SK)Zdroj.dok. International Journal of Biological Macromolecules. - : Elsevier - ISSN 0141-8130
Roč. 160, OCT 1 (2020), s. 364-371Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Cyanobacteria ; Extracellular polysaccharide ; Biological activities Vědní obor RIV CE - Biochemie Obor OECD Biochemistry and molecular biology CEP TE01020080 GA TA ČR - Technologická agentura ČR Způsob publikování Omezený přístup Institucionální podpora BU-J - RVO:67985939 UT WOS 000564748800003 EID SCOPUS 85085972436 DOI 10.1016/j.ijbiomac.2020.05.135 Anotace Complex structure of cyanobacterium Nostoc sp. exopolysaccharide (EPS), with apparent molecular weight 214 × 103 g/mol, can be deduced from its composition. Chemical and NMR analyses found four dominant sugarmonomers, namely (1→ 4)-linked α-L-arabinopyranose, β-D-glucopyranose, β-D-xylopyranose and (1→ 3)-linked β-D-mannopyranose, two different uronic acids and a lactyl group, with (1→4,6)-linked β-D-glucopyranose as the only branch point suggest a complex structure of this polymer. The dominant uronic acid is α-linked, but it remained unidentified. β-D-Glucuronic acid was present in lower amount. Their position as well as that of lactyl remained undetermined too. Different doses of orally administered EPS in guinea pigs evoked a significant decrease in cough effort and a decrease in airway reactivity. The antitussive efficacy and bronchodilator effect of higher doses of EPS were found to be similar to that of the antitussive drug codeine and the antiasthmatic salbutamol. Without significant cytotoxicity on the RAW264.7 cells, EPS stimulated themacrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator. Pracoviště Botanický ústav Kontakt Martina Bartošová, martina.bartosova@ibot.cas.cz, ibot@ibot.cas.cz, Tel.: 271 015 242 ; Marie Jakšová, marie.jaksova@ibot.cas.cz, Tel.: 384 721 156-8 Rok sběru 2021 Elektronická adresa http://hdl.handle.net/11104/0310806
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